5-HT1A RECEPTORS IN THE MEDIAN RAPHE NUCLEUS AND DORSAL HIPPOCAMPUS MAY MEDIATE ANXIOLYTIC AND ANXIOGENIC BEHAVIORS RESPECTIVELY
5-HT1A RECEPTORS IN THE MEDIAN RAPHE NUCLEUS AND DORSAL HIPPOCAMPUS MAY MEDIATE ANXIOLYTIC AND ANXIOGENIC BEHAVIORS RESPECTIVELY
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DOI：
10.1016/0014-2999(94)00473-0
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发表时间：
1994-11-03
影响因子：
5
通讯作者：
FILE, SE
中科院分区：
文献类型：
--
作者：
ANDREWS, N;HOGG, S;FILE, SE
在将5-HT 1A受体激动剂（i）-8-羟基-二丙氨基四氢萘（8-OH-DPAT，50、100或200 ng）或拮抗剂特他洛尔（3 μ g）直接给予中缝核或背海马后，观察到大鼠在焦虑社交互动测试的强光陌生条件下的行为反应。在中缝核，8-OH-DPAT（200 ng）显着增加社会互动，而不改变自发活动;低剂量是无效的。在背侧海马，双侧注射8-OH-DPAT（100 ng）显着减少社会互动，对自发活动没有影响，50和100 ng显着改变梳理。特他洛尔对中缝核给药后的社会互动没有影响，但显著增加了自发活动。双侧注射特他洛尔到背海马减少社会互动和改变梳理。这些作用与8-OH-DPAT相似，表明特他洛尔可能具有5-HT 1A受体激动剂特性。总之，本研究的结果表明，5-HT 1A体树突状自身受体和突触后受体介导的抗焦虑和焦虑的影响，分别在社会互动测试。
The behavioural response of rats in the high light unfamiliar condition of the social interaction test of anxiety was observed following direct administration of the 5-HT1A receptor agonist, (i)-8-hydroxy-dipropylaminotetralin (8-OH-DPAT, 50, 100 or 200 ng) or antagonist tertatolol (3 mu g) into the median raphe nucleus or dorsal hippocampus. In the median raphe nucleus, 8-OH-DPAT (200 ng) significantly increased social interaction without changing locomotor activity; lower doses were inactive. In the dorsal hippocampus, bilateral injection of 8-OH-DPAT (100 ng) significantly decreased social interaction, without effect on locomotor activity; both 50 and 100 ng significantly changed grooming. Tertatolol had no effect on social interaction following administration to the median raphe nucleus, but significantly increased locomotor activity. Bilateral injection of tertatolol into the dorsal hippocampus decreased social interaction and changed grooming. These effects are similar to those of 8-OH-DPAT suggesting tertatolol may have 5-HT1A receptor agonist properties. In conclusion, the findings of this study demonstrate that 5-HT1A somatodendritic autoreceptors and post-synaptic receptors mediate anxiolytic and anxiogenic effects, respectively, in the social interaction test.