Influence of local particle concentration gradient forces on the flow-mediated mass transport in a numerical model of magnetic drug targeting
Influence of local particle concentration gradient forces on the flow-mediated mass transport in a numerical model of magnetic drug targeting
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DOI：
10.1016/j.jmmm.2020.167490
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发表时间：
2020-10
影响因子：
2.7
通讯作者：
Veronica C. Gonella;F. Hanser;J. Vorwerk;S. Odenbach;D. Baumgarten
中科院分区：
文献类型：
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作者：
Veronica C. Gonella;F. Hanser;J. Vorwerk;S. Odenbach;D. Baumgarten
磁性纳米粒子已广泛应用于纳米医学领域：基于磁性药物靶向的疗法在改善当前医疗技术水平方面显示出有希望的结果。仍然需要完全了解颗粒与其承载流或周围组织的相互作用，以及颗粒间相互作用的潜在机制。这些相互作用可能会促进流体域中的颗粒聚集，从而影响治疗结果。这项研究提出了一个数值模型来描述磁性药物靶向的现实设置中的粒子磁流体动力学。重点是定量分析局部铁磁流体浓度梯度对磁流体体积力的贡献，以及研究磁流体体积力对颗粒直径和铁磁流体浓度的依赖性。结果表明，对磁流体体积力的主要贡献是磁场梯度项。然而，浓度梯度项的范围相同，因此在力公式中不能忽略。此外，还发现摩尔浓度分布随着不同的力公式和不同的摩尔流入值而变化。该模型概述了磁流体体积力随着颗粒直径和铁磁流体浓度的增加而增加。然而，这两种关系都不是线性的，而是更加复杂。所描述的方法被证明是通用的，并且进一步适用于更复杂的几何形状和场景。此外，所提出的数值模型的结果和成就首次深入了解了局部铁磁流体浓度梯度在确定磁流体体积力中的作用，并代表了进一步研究流介导的铁磁流体质量传递机制的起点。
Magnetic nanoparticles have been widely applied in the nanomedicine field: therapies based on magnetic drug targeting have shown promising results towards the improvement of the current state of the art of medical treatments. Particles interaction with their carrying flow or the surrounding tissues still needs to be completely understood, as well as the mechanisms underlying interparticle interactions. These interactions can potentially promote particles aggregation in the fluid doman and therefore influence the therapy outcome. This study presents a numerical model to describe particles magnetohydrodynamics in a realistic setup for magnetic drug targeting. The focus is a quantitative analysis of the contribution of the local ferrofluid concentration gradients to the magnetic fluid volume force, as well as an investigation on the dependence of the magnetic fluid volume force on particles diameter and ferrofluid concentration. The results show that the main contribution to the magnetic fluid volume force is the magnetic field gradients term. However, the concentration gradients term ranges in the same order of magnitude and therefore cannot be neglected in the force formulation. In addition, the molar concentration distribution has been found to change with different force formulations and with different values of the molar influx too. The model outlines that the magnetic fluid volume force increases with the particle diameter and the ferrofluid concentration. However, both relationships are not linear, but more complex. The described approach proves to be versatile and further applicable to more complex geometries and scenarios. In addition, the outcome and the achievements of the presented numerical model provide for the first time insights into the role of the local ferrofluid concentration gradients in the determination of the magnetic fluid volume force and represent a starting point for further investigations of the mechanisms underlying the flow-mediated ferrofluid mass transport.