Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
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我们对6项克罗恩病全基因组关联研究（GWAS）进行了荟萃分析，其中包括6，333例受影响的个体（病例）和15，056例对照，并对15，694例病例，14，026例对照和414例亲子三人组中的顶级关联信号进行了随访。我们确定了30个新的易感基因座，满足全基因组意义（P< 5 × 10−8）。一系列的计算机模拟分析突出了这些位点中的特定基因，并结合人工筛选，暗示了功能感兴趣的候选基因，包括SMAD 3，ERAP 2，IL 10，IL 2RA，TYK 2，FUT 2，DNMT 3A，DEND1B，BACH 2和TAGAP。结合先前确认的基因座，这些结果确定了71个不同的基因座与克罗恩病相关的全基因组显著证据。
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P< 5 × 10−8). A series ofin silicoanalyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes includingSMAD3,ERAP2,IL10,IL2RA,TYK2,FUT2,DNMT3A,DENND1B,BACH2andTAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.
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影响因子：
4.5
作者：
Libioulle C;Louis E;Hansoul S;Sandor C;Farnir F;Franchimont D;Vermeire S;Dewit O;de Vos M;Dixon A;Demarche B;Gut I;Heath S;Foglio M;Liang L;Laukens D;Mni M;Zelenika D;Van Gossum A;Rutgeerts P;Belaiche J;Lathrop M;Georges M
通讯作者：
Georges M
影响因子：
3.3
作者：
Aoh, Quyen L.;Castle, Anna M.;Castle, J. David
通讯作者：
Castle, J. David
影响因子：
30.8
作者：
Imielinski, Marcin;Baldassano, Robert N.;Griffiths, Anne;Russell, Richard K.;Annese, Vito;Dubinsky, Marla;Kugathasan, Subra;Bradfield, Jonathan P.;Walters, Thomas D.;Sleiman, Patrick;Kim, Cecilia E.;Muise, Aleixo;Wang, Kai;Glessner, Joseph T.;Saeed, Shehzad;Zhang, Haitao;Frackelton, Edward C.;Hou, Cuiping;Flory, James H.;Otieno, George;Chiavacci, Rosetta M.;Grundmeier, Robert;Castro, Massimo;Latiano, Anna;Dallapiccola, Bruno;Stempak, Joanne;Abrams, Debra J.;Taylor, Kent;McGovern, Dermot;Heyman, Melvin B.;Ferry, George D.;Kirschner, Barbara;Lee, Jessica;Essers, Jonah;Grand, Richard;Stephens, Michael;Levine, Arie;Piccoli, David;Van Limbergen, Johan;Cucchiara, Salvatore;Monos, Dimitri S.;Guthery, Stephen L.;Denson, Lee;Wilson, David C.;Grant, Struan F. A.;Daly, Mark;Silverberg, Mark S.;Satsangi, Jack;Hakonarson, Hakon
通讯作者：
Hakonarson, Hakon
影响因子：
56.9
作者：
Duerr, Richard H.;Taylor, Kent D.;Cho, Judy H.
通讯作者：
Cho, Judy H.
影响因子：
82.9
作者：
Loser, Karin;Mehling, Annette;Beissert, Stefan
通讯作者：
Beissert, Stefan