Mechanism of neutralization of budded Autographa californica nuclear polyhedrosis virus by a monoclonal antibody: Inhibition of entry by adsorptive endocytosis.
Mechanism of neutralization of budded Autographa californica nuclear polyhedrosis virus by a monoclonal antibody: Inhibition of entry by adsorptive endocytosis.
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DOI：
10.1016/0042-6822(85)90107-2
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发表时间：
1985-05
期刊：
影响因子：
3.7
通讯作者：
L. Volkman;P. Goldsmith
中科院分区：
文献类型：
--
作者：
L. Volkman;P. Goldsmith
Autographa californicanuclear polyhedrosis virus (AcNPV) is characterized by two different phenotypes, each with a specific role in the life cycle of the virus in nature. They differ widely in infectivity bothin vivoandin vitro, and are neutralized by different populations of antibodies. A monoclonal antibody designated AcV1neutralizes one phenotype, BV, by reacting with a major envelope antigen not present on the other phenotype. BV can functionally enter cells by two different pathways and AcV1neutralizes BV by preventing it from using its preferred pathway, adsorptive endocytosis. Further, a “nonneutralizable” fraction of BV in the presence of antibody excess enters by the alternative pathway. The difference in infectivity between the two phenotypes of AcNPV can be attributed to mechanisms of functional entry, as only BV can enter by the more efficient adsorptive endocytosis.
