Two types of increases in free Ca2+ evoked by odor in isolated frog olfactory receptor neurons.
Two types of increases in free Ca2+ evoked by odor in isolated frog olfactory receptor neurons.
复制标题
离体青蛙嗅觉受体神经元中气味引起的两种类型的游离 Ca2+ 增加。
DOI：
10.1097/00001756-199105000-00003
复制
发表时间：
1991
期刊：
影响因子：
1.7
通讯作者：
M. Takebayashi
中科院分区：
文献类型：
--
作者：
T. Sato;J. Hirono;M. Tonoike;M. Takebayashi
嗅觉传导涉及第二信使相关的酶和cAMP门控的K+和Ca 2+通道，已知其受Ca 2+调节。嗅觉神经元胞浆内游离Ca ~（2+）浓度（[Ca ~（2+）]i）在气味剂或毛喉素作用下升高，Ca ~（2+）内流参与了嗅觉神经元的适应性变化。[Ca 2 +]i的增加低于静息水平的2至3倍，并且持续26 s（平均值，n = 18）。增加是由于两个途径：Ca 2+内流和释放。[Ca 2 +]i的缓慢增加，毛喉素类似于citralva。结果表明，Citralva的反应伴随着细胞内cAMP和Ca ~（2+）内流或释放的增加，导致[Ca ~（2+）]i的瞬时增加。
Olfactory transduction involves second messenger-related enzymes and cAMP-gated, K+ and Ca2+ channels, which are known to be regulated by Ca2+. We report here that cytosolic free Ca2+ concentration ([Ca2+]i) in olfactory receptor neuron was increased by odorants or forskolin and Ca2+ influx contributed to the adaptation. The increases in [Ca2+]i were below two to three-fold of resting level and transient for 26 s (mean value, n = 18). The increases were due to two pathways: Ca2+ influx and release. The slow increases in [Ca2+]i by forskolin resembled those by citralva. It was suggested that the responses to citralva were accompanied by increases in intracellular cAMP and Ca2+ influx or release leading to transient increases in [Ca2+]i.