Decreased left ventricular longitudinal contraction in normotensive and normoalbum inuric patients with Type II diabetes mellitus: a Doppler tissue tracking and strain rate echocardiography study
Decreased left ventricular longitudinal contraction in normotensive and normoalbum inuric patients with Type II diabetes mellitus: a Doppler tissue tracking and strain rate echocardiography study
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DOI：
10.1042/cs20020303
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发表时间：
2003-07-01
期刊：
影响因子：
6
通讯作者：
Mogensen, CE
中科院分区：
文献类型：
--
作者：
Andersen, NH;Poulsen, SH;Mogensen, CE
II型糖尿病与射血分数保留的充血性心力衰竭有关。这组患者被认为有孤立的舒张期功能障碍；然而，之前还没有人研究过左心室的纵向收缩。本研究的目的是探讨血压正常、射血分数正常的II型糖尿病患者左心室纵向收缩的情况。我们检查了32例血压正常的II型糖尿病患者，其射血分数和短轴缩短率分别为0.55和0.25。排除标准为心绞痛、心脏瓣膜病、蛋白尿、视网膜病变或神经病。正常人(n=32)作为对照。16节段运动幅度模型评价左心室纵向收缩，并计算各节段的平均值作为组织追踪记分指数。各节段的峰值收缩速度和应变率也得到了测量。II型糖尿病患者的组织追踪评分指数显著低于正常对照组(5.8±1.6 mm比7.7±1.1 mm；P
Type II diabetes mellitus is associated with congestive heart failure with preserved ejection fraction. This group of patients has been assumed to have isolated diastolic dysfunction; however, the longitudinal systolic contraction of the left ventricle has not been studied previously. The objective of the present study was to investigate the longitudinal contraction of the left ventricle in normotensive Type II diabetes mellitus patients with normal ejection fraction. We examined 32 normotensive patients with Type II diabetes mellitus with ejection fraction >0.55 and fractional shortening >0.25. Exclusion criteria were angina pectoris, cardiac valve disease, albuminuria, retinopathy or neuropathy. Normal subjects (n=32) served as controls. A 16-segment model of motion amplitude assessed left ventricular longitudinal contraction and the average of the segments was calculated as the tissue tracking score index. Peak systolic velocity and strain rate was also obtained in each segment. Patients with Type II diabetes mellitus had a significantly lower tissue tracking score index compared with normal subjects (5.8+/-1.6 mm compared with 7.7+/-1.1 mm; P