miRNA expression is highly sensitive to a drug therapy in Parkinson's disease
miRNA expression is highly sensitive to a drug therapy in Parkinson's disease
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DOI：
10.1016/j.parkreldis.2014.10.018
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发表时间：
2015-01-01
影响因子：
4.1
通讯作者：
Slominsky, Petr A.
中科院分区：
文献类型：
--
作者：
Alieva, Anelya Kh.;Filatova, Elena V.;Slominsky, Petr A.
背景：miRNAs可能在帕金森病的发病机制中发挥作用。有必要继续寻找新的miRNAs，可能会影响帕金森病神经退行性病变的发展，方法：20例未经治疗的帕金森病患者和18例治疗的帕金森病患者（Hoehn和Yahr评分1-2）进行了研究。结果：与对照组相比，帕金森病治疗组患者外周血淋巴细胞中miR-7、miR-9- 3 p、miR-9- 5 p、miR-129和miR-132的水平增加了3倍以上。结论：很可能miRNA对药物治疗非常敏感，并且观察到的治疗效果可能与帕金森病患者中这些miRNA及其靶基因水平的变化相关。(C)2014爱思唯尔有限公司版权所有。
Background: miRNAs may play a role in the pathogenesis of Parkinson's disease. It is necessary to continue the search for new miRNAs that may affect the development of neurodegeneration in Parkinson's disease.Methods: 20 untreated patients with Parkinson's disease and 18 treated patients with Parkinson's disease (Hoehn and Yahr scores 1-2) were studied. An analysis of the levels of 11 miRNAs in the peripheral blood lymphocytes of patients was carried out using reverse transcription followed by real-time PCR.Results: The levels of miR-7, miR-9-3p, miR-9-5p, miR-129, and miR-132 were increased by more than three times in treated patients with Parkinson's disease compared with those of the controls.Conclusions: It is probable that miRNAs are very sensitive to drug therapy and that the effects of therapy observed may be associated with changes in the levels of these miRNAs and their target genes in patients with Parkinson's disease. (C) 2014 Elsevier Ltd. All rights reserved.