Bioactive polymeric scaffolds for tissue engineering.
Bioactive polymeric scaffolds for tissue engineering.
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DOI：
10.1016/j.bioactmat.2016.11.001
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发表时间：
2016-12
影响因子：
18.9
通讯作者：
Kumbar SG
中科院分区：
文献类型：
--
作者：
Stratton S;Shelke NB;Hoshino K;Rudraiah S;Kumbar SG
各种各样的工程支架已被创建用于组织工程使用聚合物，陶瓷及其复合材料。仿生学已被用于大多数三维（3D）支架设计，无论是在物理化学性质还是在上级组织再生的生物活性方面。通过盐浸提、颗粒烧结、水凝胶和光刻法制造的支架已经成功地促进体外细胞生长和体内组织再生。来源于整个器官或组织的脱细胞化的支架系统由于其有保证的生物相容性和生物活性而受到欢迎。传统的支架制造技术通常无法以更高的分辨率创建复杂的结构，不可再现并且涉及多个步骤。3D打印技术克服了传统技术的几个局限性，使其更容易采用几种热塑性塑料和水凝胶来制造用于组织工程和药物输送的微纳米结构支架和装置。这篇综述强调了支架制造方法，重点是通过基质孔隙，生物活性和降解速率优化支架性能，使组织再生。综述强调了生物活性支架介导的神经，肌肉，肌腱/韧带和骨再生的几个例子。无论优化所需的努力如何，随着本文中讨论的一些方法变得更加精简，预计在不久的将来，3D支架的使用将从实验室转移到日常生活中。强调了理想的生物材料基支架的要求。讨论了力学性能与孔隙率的关系。讨论了几种支架制造技术的优缺点。提供的组织工程策略示例
A variety of engineered scaffolds have been created for tissue engineering using polymers, ceramics and their composites. Biomimicry has been adopted for majority of the three-dimensional (3D) scaffold design both in terms of physicochemical properties, as well as bioactivity for superior tissue regeneration. Scaffolds fabricated via salt leaching, particle sintering, hydrogels and lithography have been successful in promoting cell growth in vitro and tissue regeneration in vivo. Scaffold systems derived from decellularization of whole organs or tissues has been popular due to their assured biocompatibility and bioactivity. Traditional scaffold fabrication techniques often failed to create intricate structures with greater resolution, not reproducible and involved multiple steps. The 3D printing technology overcome several limitations of the traditional techniques and made it easier to adopt several thermoplastics and hydrogels to create micro-nanostructured scaffolds and devices for tissue engineering and drug delivery. This review highlights scaffold fabrication methodologies with a focus on optimizing scaffold performance through the matrix pores, bioactivity and degradation rate to enable tissue regeneration. Review highlights few examples of bioactive scaffold mediated nerve, muscle, tendon/ligament and bone regeneration. Regardless of the efforts required for optimization, a shift in 3D scaffold uses from the laboratory into everyday life is expected in the near future as some of the methods discussed in this review become more streamlined. The requirements for an ideal biomaterial-based scaffold are highlighted. The relationship between mechanical properties and porosity is discussed. Several scaffold fabrication techniques are discussed with advantages and disadvantages. Examples of tissue engineering strategies provided