Effects of latanoprost and timolol-XE on hydrodynamics in the normal eye.
Effects of latanoprost and timolol-XE on hydrodynamics in the normal eye.
复制标题
拉坦前列素和噻吗洛尔-XE 对正常眼流体动力学的影响。
DOI：
10.1016/s0002-9394(00)00401-3
复制
发表时间：
2000
影响因子：
4.2
通讯作者：
Friberg,T
中科院分区：
文献类型：
--
作者：
Sponsel,WE;Mensah,J;Kiel,JW;Remky,A;Trigo,Y;Baca,W;Friberg,T
目的比较拉坦前列素和噻吗洛尔-XE对健康成人眼压和血流灌注以及巩膜外静脉压的影响。方法双盲、安慰剂对照交叉研究，为期一周的睡前治疗，使用一滴药物，对侧使用安慰剂，随后进行为期3周的冲洗和替代药物/对侧安慰剂重复。通过压平和呼吸压测量来测量眼内压，提供脉动眼循环估计。测量巩膜外静脉压（Friberg 法）。 结果 20 名受试者参与（5 名男性，15 名女性；平均年龄，39 岁（范围，21 至 55 岁）；平均基线眼压，13.4 mm Hg）。在开始使用拉坦前列素（-2.0 mm Hg；P < .0001）治疗后的第二天早上，这些受试者的眼压下降幅度大于噻吗洛尔-XE（-0.9 mm Hg；P = .051）（拉坦前列素与噻吗洛尔 ΔP = .008）。当晚使用拉坦前列素（-3.2 mm Hg；P < .0001）时，这种降眼压作用仍然显着，但使用噻吗洛尔 XE（-1.0 mm Hg；P = .2）则不然。到第 8 天早上，拉坦前列素组的平均眼压仍低于基线 3.2 mm Hg，噻吗洛尔-XE 组的平均眼压仍低于基线 2.3 mm Hg（两种药物的 P < .0001）。这两种药物都不会改变巩膜外静脉压。在使用两种药物降低眼压相当的 9 名受试者的亚组中，拉坦前列素治疗与在一周的治疗间隔内平均脉动眼部血流增加 16.7% (P = .04) 相关，始终高于同一受试者的噻吗洛尔-XE 治疗期间。 结论 拉坦前列素导致血压正常的正常眼眼压在一夜之间下降，并且两种药物在 1 周内显着降低眼内压。在两种药物的治疗过程中，眼压始终高于巩膜外静脉压。拉坦前列素可增强脉动性眼部灌注，而噻吗洛尔-XE 治疗则未见这种情况。
PURPOSETo compare the effects of latanoprost and timolol-XE on ocular pressure and perfusion in healthy adults, with respect to episcleral venous pressure.METHODSA double-masked, placebo-controlled crossover study of weeklong bedtime treatment with one drop of drug, with placebo contralaterally, followed by a 3-week washout and alternate-drug/contralateral-placebo repeat. Intraocular pressure was measured by applanation and by pneumotonometry, providing pulsatile ocular circulatory estimates. Measurements of episcleral venous pressure were obtained (Friberg method).RESULTSTwenty subjects participated (five men, 15 women; mean age, 39 years (range, 21 to 55 years); mean baseline intraocular pressure, 13.4 mm Hg). A greater decrease in intraocular pressure was seen among these subjects the morning after initiating treatment with latanoprost (−2.0 mm Hg; P < .0001) than with timolol-XE (−0.9 mm Hg; P = .051) (latanoprost versus timolol ΔP = .008). This ocular hypotensive effect remained significant that evening with latanoprost (−3.2 mm Hg; P < .0001) but not with timolol XE (−1.0 mm Hg; P = .2). By the morning of day 8, mean intraocular pressure remained 3.2 mm Hg below baseline with latanoprost and 2.3 mm Hg below baseline with timolol-XE (P < .0001 for both drugs). Neither drug altered episcleral venous pressure. Among a subgroup of nine subjects with comparable intraocular pressure reductions with the two drugs, latanoprost treatment was associated with a 16.7% increase in mean pulsatile ocular blood flow (P = .04) through the weeklong treatment interval, consistently higher than during timolol-XE treatment of the same subjects.CONCLUSIONLatanoprost caused an overnight decrease in intraocular pressure in normotensive normal eyes, and both drugs significantly reduced intraocular pressure within 1 week. Intraocular pressure remained higher than episcleral venous pressure throughout treatment with both drugs. Latanoprost was associated with enhanced pulsatile ocular perfusion not seen with timolol-XE treatment.