MYELINATED AFFERENT FIBRES RESPONDING SPECIFICALLY TO NOXIOUS STIMULATION OF SKIN
MYELINATED AFFERENT FIBRES RESPONDING SPECIFICALLY TO NOXIOUS STIMULATION OF SKIN
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DOI：
10.1113/jphysiol.1967.sp008227
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发表时间：
1967-01-01
影响因子：
5.5
通讯作者：
PERL, ER
中科院分区：
文献类型：
--
作者：
BURGESS, PR;PERL, ER
用微针记录猫后肢毛皮的单个初级传入纤维，研究其受体的特性。描述了513根513根光纤在51m/s以下的传输特性。74条传导速度在6到37米/秒之间的纤维被归类为伤害性感受器，因为它们只对皮肤的破坏性机械刺激做出反应。这些纤维在用锯齿钳夹住皮肤或切割皮肤时反应最大。刺激性的高温、刺激性的寒冷、酸性物质和皮肤切割处注射的缓激肽都不能引起这些感受器的放电。它们的感受野一般长2-5厘米，宽1-2厘米。5厘米宽，由响应点(直径在1毫米以下)组成，由无反应区隔开。有一种趋势是，传导最慢的纤维被归类为最不敏感的。其他传入纤维的感受区与伤害性感受器相似；然而，它们是由大量但不有害的机械变形所兴奋的。它们的传导速度与伤害性感受器的传导速度重叠，并延伸到51米/秒；最快速的传导纤维往往对机械刺激最敏感。这些不敏感的机械感受器或中等压力感受器比伤害性感受器适应得更慢。大多数细小有髓轴突起源于毛发受体，传导速度集中在14~22m/s之间。这些观察结果可能与疼痛和疼痛的典型反应有关。
The characteristics of receptors from the hairy skin of the hind limb of cat were studied by recording from single primary afferent fibres with fine micropipettes. The distinctive features of 513 fibres conducting under 51 m/sec are described. Seventy-four fibres conducting between 6 and 37 m/sec were classified as nociceptors because they responded only to damaging mechanical stimulation of the skin. These fibres responded maximally to pinching the skin with a serrated forceps or to cutting the skin. Noxious heat, noxious cold, acid applied to the receptive field and bradykinin injected into skin cuts did not evoke discharges from such receptors. Typically their receptive fields were 2-5 cm long by 1-2. 5 cm wide and consisted of responsive spots (under 1 mm diameter) separated by unresponsive areas. There was a tendency for the most slowly conducting fibres so classified to be the least sensitive. Other afferent fibres had receptive fields similar to the nociceptors; however, they were excited by substantial but not noxious mechanical deformation. Their conduction velocities overlapped those of the nociceptors and extended upwards to 51 m/sec; the most rapidly conducting fibres tended to be the most sensitive to mechanical stimuli. These insensitive mechanoreceptors or moderate pressure receptors adapted more slowly than the nociceptors. The majority of fine myelinated axons originated from hair receptors and had conduction velocities concentrated between 14 and 22 m/sec. The possible relation of these observations to pain and reactions typical of pain is considered.