Poor Long-Term Functional Outcome After Stroke Among Adults Aged 18 to 50 Years Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation (FUTURE) Study

Poor Long-Term Functional Outcome After Stroke Among Adults Aged 18 to 50 Years Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation (FUTURE) Study
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DOI：
10.1161/strokeaha.113.004411
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发表时间：
2014-04-01
期刊：
STROKE
影响因子：
8.3
通讯作者：
de Leeuw, Frank-Erik
de Leeuw, Frank-Erik
中科院分区：
医学1区
文献类型：
--
作者：
Synhaeve, Nathalie E.;Arntz, Renate M.;de Leeuw, Frank-Erik

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背景和目的中风对年轻人的生活有显著的影响；因此，我们研究了18 - 50岁成人短暂性脑缺血发作、缺血性卒中或脑出血后的长期功能结局。方法对1980年1月1日至2010年11月1日收治的722例首次中风的年轻患者进行研究。功能结局采用改良Rankin量表和日常生活工具活动量表按脑卒中亚型进行评估。结果平均随访9.1年（SD, 8.2）年后，32.0%的患者功能预后较差（改良Rankin量表，bb0.2）；缺血性中风为36.5%，脑出血为49.3%，短暂性脑缺血发作为16.8%。在随访中，10.8%的短暂性脑缺血发作、14.6%的缺血性脑卒中和18.2%的脑出血患者的预后较差。
Background and Purpose Stroke in young adults has a dramatic effect on life; therefore, we investigated the long-term functional outcome after transient ischemic attack, ischemic stroke, or intracerebral hemorrhage in adults aged 18 to 50 years.Methods We studied 722 young patients with first-ever stroke admitted between January 1, 1980, and November 1, 2010. Functional outcome was assessed by stroke subtype with the modified Rankin Scale and Instrumental Activities of Daily Living scale.Results After a mean follow-up of 9.1 (SD, 8.2) years, 32.0% of all patients had a poor functional outcome (modified Rankin Scale, >2); for ischemic stroke, this was 36.5%, for intracerebral hemorrhage 49.3%, and for transient ischemic attack 16.8%. At follow-up, 10.8% of transient ischemic attack, 14.6% of ischemic stroke, and 18.2% of intracerebral hemorrhage patients had a poor outcome as assessed by Instrumental Activities of Daily Living (