Aptamers: active targeting ligands for cancer diagnosis and therapy.
Aptamers: active targeting ligands for cancer diagnosis and therapy.
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DOI：
10.7150/thno.10257
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发表时间：
2015
期刊：
影响因子：
12.4
通讯作者：
Zhao JX
中科院分区：
文献类型：
--
作者：
Wu X;Chen J;Wu M;Zhao JX
核酸适体是一组有前途的识别单元，包括DNA、RNA和肽类适体，它们可以特异性地与靶分子和细胞结合。由于其对靶点的特异性和高亲和力，适体在需要选择性识别单元的各个领域引起了极大的关注。它们已被用于生物传感，药物输送，疾病诊断和治疗（特别是癌症治疗）。本文综述了近年来DNA和RNA适体在肿瘤诊断治疗中的应用。适体与癌症相关标志物和癌细胞的特异性结合能力确保了其用于癌症早期诊断的高性能。同时，核酸适体对癌细胞和组织的高效靶向作用为肿瘤显像和治疗提供了一种很有前途的显像剂和药物递送途径。此外，随着纳米科学和纳米技术的发展，适配体与功能性纳米材料的结合为制备针对不同类型癌症的治疗诊断剂铺平了令人兴奋的道路，这可能是癌症治疗的有力工具。
Aptamers, including DNA, RNA and peptide aptamers, are a group of promising recognition units that can specifically bind to target molecules and cells. Due to their excellent specificity and high affinity to targets, aptamers have attracted great attention in various fields in which selective recognition units are required. They have been used in biosensing, drug delivery, disease diagnosis and therapy (especially for cancer treatment). In this review, we summarized recent applications of DNA and RNA aptamers in cancer theranostics. The specific binding ability of aptamers to cancer-related markers and cancer cells ensured their high performance for early diagnosis of cancer. Meanwhile, the efficient targeting ability of aptamers to cancer cells and tissues provided a promising way to deliver imaging agents and drugs for cancer imaging and therapy. Furthermore, with the development of nanoscience and nanotechnology, the conjugation of aptamers with functional nanomaterials paved an exciting way for the fabrication of theranostic agents for different types of cancers, which might be a powerful tool for cancer treatment.
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影响因子：
46.9
作者：
Dassie, Justin P.;Liu, Xiu-ying;Thomas, Gregory S.;Whitaker, Ryan M.;Thiel, Kristina W.;Stockdale, Katie R.;Meyerholz, David K.;McCaffrey, Anton P.;McNamara, James O., II;Giangrande, Paloma H.
通讯作者：
Giangrande, Paloma H.
影响因子：
17.1
作者：
Bagalkot V;Gao X
通讯作者：
Gao X
适体介导的siRNA传递。
影响因子：
14.9
作者：
Chu, Ted C.;Twu, Karen Y.;Ellington, Andrew D.;Levy, Matthew
通讯作者：
Levy, Matthew
影响因子：
5.6
作者：
BANGHAM, AD;STANDISH, MM;WATKINS, JC
通讯作者：
WATKINS, JC
影响因子：
16.6
作者：
Cao, Zehui;Tong, Rong;Lu, Yi
通讯作者：
Lu, Yi