Prevalence and Determinants of Chronic Kidney Disease Among Hypertensive Cameroonians According to Three Common Estimators of the Glomerular Filtration Rate
Prevalence and Determinants of Chronic Kidney Disease Among Hypertensive Cameroonians According to Three Common Estimators of the Glomerular Filtration Rate
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DOI：
10.1111/jch.12781
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发表时间：
2016-05-01
影响因子：
2.8
通讯作者：
Blackett，Kathleen
中科院分区：
文献类型：
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作者：
Kaze，Francois Folefack;Kengne，Andre-Pascal;Blackett，Kathleen
高血压是肾脏疾病的危险因素，而肾脏疾病又是高血压的前兆。作者评估了336名喀麦隆高血压成人（平均年龄60.9±11.3岁，63.4%为女性）在yound<s:1>的患病率和慢性肾脏疾病（CKD）的决定因素。任何估计肾小球滤过率<60 mL/min/1.73 m2的参与者，无论使用何种公式（Cockcroft‐Gault [CG]、肾病患者饮食改变[MDRD]和慢性肾病流行病学合作[CKD‐EPI]）和/或尿量尺均在3个月后复查。参与者表现出糖尿病（18.5%）、血脂异常（17.6%）、痛风/高尿酸血症（10.7%）、超重/肥胖（68.8%）、自我用药（37.5%）和饮酒（33.3%）的高患病率。265例（78.9%）患者高血压未得到控制。根据MDRD、CKD‐EPI和CG方程，CKD的患病率分别为49.7%、50.0%和52.1%。高龄、肥胖和高血压严重程度是CKD的决定因素。近一半的高血压患者患有CKD，无论使用何种估计器，都是由众所周知的危险因素预测的。
Hypertension is a risk factor for renal diseases, which, in turn, are precursors of hypertension. The authors assessed the prevalence and determinants of chronic kidney disease (CKD) among 336 hypertensive adult Cameroonians (mean age, 60.9±11.3 years; 63.4% women) at Yaoundé. Any participant with an estimated glomerular filtration rate <60 mL/min/1.73 m2regardless of the equation used (Cockcroft‐Gault [CG], Modification of Diet in Renal Disease [MDRD], and Chronic Kidney Disease Epidemiology Collaboration [CKD‐EPI]) and/or dipstick proteinuria was reviewed 3 months later. Participants presented a high prevalence of diabetes (18.5%), dyslipidemia (17.6%), gout/hyperuricemia (10.7%), overweight/obesity (68.8%), self‐medication (37.5%), and alcohol consumption (33.3%). Hypertension was uncontrolled in 265 patients (78.9%). The prevalence of CKD was 49.7%, 50.0%, and 52.1% according to MDRD, CKD‐EPI, and CG equations, respectively. Advanced age, adiposity, and severity of hypertension were determinants of CKD.Nearly half of the hypertensive patients had CKD regardless of the estimators used, predicted by well‐known risk factors.