Selective depletion of regulatory T cell subsets by docetaxel treatment in patients with nonsmall cell lung cancer.
Selective depletion of regulatory T cell subsets by docetaxel treatment in patients with nonsmall cell lung cancer.
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通过多西紫杉醇治疗非小细胞肺癌患者选择性消除调节性 T 细胞亚群。
DOI：
10.1155/2014/286170
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发表时间：
2014
影响因子：
4.1
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Li JY;Duan XF;Wang LP;Xu YJ;Huang L;Zhang TF;Liu JY;Li F;Zhang Z;Yue DL;Wang F;Zhang B;Zhang Y
调节性T （Treg）细胞是维持免疫稳态的有效抑制因子。Treg的积累可以抑制癌症患者的有效免疫反应，导致肿瘤的发生和进展。尽管有直接的细胞毒性，但据报道，一些化疗药物可以消耗Treg细胞，从而改善癌症患者的预后。Treg细胞是一个异质性的群体，至少有三个不同的亚群，非抑制性，静止和激活的Treg细胞。然而，肺癌患者Treg细胞亚群的特征以及化疗如何影响Treg细胞仍然是一个谜。在这项研究中，我们首先分析了40名非小细胞肺癌（NSCLC）患者和20名健康供者外周血样本中的Treg细胞亚群。Treg细胞，特异性激活的Treg细胞亚群，在NSCLC患者中显著增加。与非抑制性Treg细胞相比，活化的Treg细胞表达更高水平的CD39，主要产生抑制性细胞因子。体外实验显示，多西紫杉醇降低了Treg细胞的所有三个亚群。更重要的是，我们发现在17例NSCLC患者中，以多西他赛为基础的化疗在4个治疗周期后显著降低了所有三个Treg亚群。综上所述，本研究揭示了NSCLC患者化疗前后各种Treg细胞亚群的动态变化，为活化的Treg细胞作为化疗的潜在靶点提供了依据。
Regulatory T (Treg) cells are potent suppressors that maintain immune homeostasis. Accumulation of Treg can inhibit effective immune responses in cancer patients, leading to tumor development and progression. Despite direct cytotoxicity, several chemotherapeutic drugs have been reported to deplete Treg cells for better prognosis for cancer patients. Treg cells are a heterogenous population with at least three different subsets, nonsuppressive, resting, and activated Treg cells. However, the characteristics of Treg cell subsets in lung cancer patients and how chemotherapy affects Treg cells remain elusive. In this study, we first analyzed Treg cell subsets in peripheral blood samples from 40 nonsmall cell lung cancer (NSCLC) patients and 20 healthy donors. Treg cells, specifically activated Treg cell subset, significantly increased in patients with NSCLC. Compared to nonsuppressive Treg cells, activated Treg cells expressed higher level of CD39 and predominantly produced inhibitory cytokines. In vitro assay showed that docetaxel reduced all three subsets of Treg cells. More importantly, we found docetaxel-based chemotherapy significantly decreased all three Treg subsets after 4 cycles of treatment in 17 NSCLC patients. Taken together, this study revealed dynamic changes of various Treg cell subsets in NSCLC patients before and after chemotherapy, providing activated Treg cells as a potential target for chemotherapy.
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DOI：
10.4049/jimmunol.1200936
发表时间：
2012-12-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Schmitt EG;Haribhai D;Williams JB;Aggarwal P;Jia S;Charbonnier LM;Yan K;Lorier R;Turner A;Ziegelbauer J;Georgiev P;Simpson P;Salzman NH;Hessner MJ;Broeckel U;Chatila TA;Williams CB
通讯作者：
Williams CB
影响因子：
5.4
作者：
Schuler, Patrick J.;Schilling, Bastian;Harasymczuk, Malgorzata;Hoffmann, Thomas K.;Johnson, Jonas;Lang, Stephan;Whiteside, Theresa L.
通讯作者：
Whiteside, Theresa L.
影响因子：
20.3
作者：
Borsellino, Giovanna;Kleinewietfeld, Markus;Falk, Kirsten
通讯作者：
Falk, Kirsten
头颈癌患者调节性 T 细胞中的核酸外切酶表达和活性增加。
影响因子：
11.5
作者：
Mandapathil, Magis;Szczepanski, Miroslaw J.;Szajnik, Marta;Ren, Jin;Lenzner, Diana E.;Jackson, Edwin K.;Gorelik, Elieser;Lang, Stephan;Johnson, Jonas T.;Whiteside, Theresa L.
通讯作者：
Whiteside, Theresa L.
肿瘤浸润的调节性T细胞抑制内源性细胞毒性T细胞对肺腺癌的反应。
DOI：
10.4049/jimmunol.1301317
发表时间：
2013-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Ganesan AP;Johansson M;Ruffell B;Yagui-Beltrán A;Lau J;Jablons DM;Coussens LM
通讯作者：
Coussens LM