A case of congenital nephrotic syndrome associated with positive C1q immunofluorescence
A case of congenital nephrotic syndrome associated with positive C1q immunofluorescence
复制标题
C1q免疫荧光阳性先天性肾病综合征一例
DOI：
10.1007/bf00857571
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Katsumaro Aida
中科院分区：
文献类型：
--
作者：
Mizue Kuwano;Yuhei Ito;Y. Amamoto;Katsumaro Aida
我们报告一位1个月大的女婴，患有先天性肾病综合症，并有不寻常的组织学发现。免疫荧光显微镜下可见C1q颗粒系膜沉积，电子显微镜下可见电子致密的系膜沉积。她的重度蛋白尿逐渐减少，类固醇治疗没有明显效果。在整个观察期间，她的肾功能都是正常的。该患者的临床表现和组织病理学特征与C1q肾病相一致。
We present a 1-month-old girl with a congenital nephrotic syndrome and unusual histological findings. Immunofluorescence microscopy demonstrated granular mesangial deposition of C1q and electron microscopy revealed electron-dense mesangial deposits. Her heavy proteinuria gradually decreased and the steroid therapy did not have a significant effect. Her renal function was normal throughout the entire period of observation. The clinical evidence and histopathological features of this patient were compatible with C1q nephropathy.