Early bone formation adjacent to rough and turned endosseous implant surfaces - An experimental study in the dog
Early bone formation adjacent to rough and turned endosseous implant surfaces - An experimental study in the dog
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DOI：
10.1111/j.1600-0501.2004.01082.x
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发表时间：
2004-08-01
影响因子：
4.3
通讯作者：
Lindhe, J
中科院分区：
文献类型：
--
作者：
Abrahamsson, I;Berglundh, T;Lindhe, J
目的：验证所提出的模型(Berglundh et al.材料和方法：用于早期愈合研究的装置具有与实心螺纹式种植体相对应的几何形状，具有SLA或T表面构型。在丝线区域(骨内部分)内准备了一个圆周沟槽，建立了一个几何上清晰的创口腔。20只拉布拉多犬接受了总共160个实验装置，以评估2小时至12周的愈合情况。磨片和脱钙片均取自近中/远中和颊/舌装置部位。对磨片进行了组织计量学和形态计量学分析，并对脱钙片中的组织成分进行了形态计量学分析。结果：磨片提供了组织形成的各个阶段的概况，而脱钙的薄片能够更详细地研究SLA和T表面的骨组织建模和重塑过程中的事件。最初空的创口腔被凝结物和肉芽组织占据，取而代之的是临时基质。骨形成过程在第一周就已经开始了。新生骨出现在切开骨床的侧缘，与母骨呈连续状，但在SLA表面，与母骨有一定距离的编织骨。4周后，平行纤维和/或板层状骨以及骨髓取代了该原始骨。与T室相比，SLA室有更多的骨与装置的接触，更多的初始编织骨和更早的板层骨形成。结论：骨整合在其建立和维持过程中都是一个动态的过程。虽然SLA和T表面的愈合表现出相似的吸收和对位事件的特征，但SLA的骨整合速度和程度优于T腔。
Objective: To validate a proposed model (Berglundh et al. 2003) and to evaluate the rate and degree of osseointegration at turned (T) and sand blasted and acid etched (SLA) implant surfaces during early phases of healing.Material and methods: The devices used for the study of early healing had a geometry that corresponded to that of a solid screw implant with either a SLA or a T surface configuration. A circumferential trough had been prepared within the thread region (intra-osseous portion) that established a geometrically well-defined wound chamber. Twenty Labrador dogs received totally 160 experimental devices to allow the evaluation of healing between 2 h and 12 weeks. Both ground and decalcified sections were prepared from mesial/distal and buccal/lingual device sites. Histometric and morphometric analyses of the ground sections and morphometric analysis of the tissue components in decalcified sections were performed.Results: The ground sections provided an overview of the various phases of tissue formation, while the decalcified, thin sections enabled a more detailed study of events involved in bone tissue modeling and remodeling for both SLA and T surfaces. The initially empty wound chamber became occupied with a coagulum and a granulation tissue that was replaced by a provisional matrix. The process of bone formation started already during the first week. The newly formed bone present at the lateral border of the cut bony bed appeared to be continuous with the parent bone, but on the SLA surface woven bone was also found at a distance from the parent bone. Parallel-fibered and/or lamellar bone as well as bone marrow replaced this primary bone after 4 weeks. In the SLA chambers, more bone-to-device contact, more initial woven bone and earlier lamellar bone formation was found than in the T chambers.Conclusion: Osseointegration represents a dynamic process both during its establishment and its maintenance. While healing showed similar characteristics with resorptive and appositional events for both SLA and T surfaces, the rate and degree of osseointegration were superior for the SLA compared with the T chambers.