Evaluation of various silver-containing dressing on infected excision wound healing study
Evaluation of various silver-containing dressing on infected excision wound healing study
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DOI：
10.1007/s10856-014-5152-1
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发表时间：
2014-05-01
影响因子：
3.7
通讯作者：
Lin, Jui-Hsiang
中科院分区：
文献类型：
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作者：
Lin, Yu-Hsin;Hsu, Wei-Shan;Lin, Jui-Hsiang
含银敷料已广泛用于控制伤口感染。然而，敷料中不同浓度的银与其抗菌活性和伤口愈合功效之间的关系仍不清楚。在本研究中，我们（与Bio-medical Carbon Technology合作）研究了各种含银活性炭纤维，以了解不同银浓度对含银敷料疗效的影响。我们的研究结果表明，各种含银活性炭纤维表现出良好的抗菌效果和生物相容性方面的细胞活力和银浓度对细胞生长的影响较小。感染切除伤口模型表明，与含银活性炭纤维和其他市售含银敷料相比，通过促进肉芽形成和胶原蛋白沉积来辅助伤口愈合。同时，银离子只能被完整皮肤限制在表皮中。在应用于伤口区域的过程中，可以检测到血清银的暂时增加，但是在去除含银活性炭纤维后，这种升高的血清银水平降低到细微的水平。
Silver-containing dressings have been widely used for controlling wound infection. However, the relationship between different concentrations of silver in dressings and their antimicrobial activities and wound-healing efficacies remains unclear. In the present study, we (in cooperation with Bio-medical Carbon Technology) investigated various silver-containing activated carbon fibers to understand the effects of different silver concentrations on the efficacies of a silver containing dressing. Our results indicated that various silver-containing activated carbon fibers exhibited good antibacterial effects and biocompatibility in terms of cell viability and that silver concentration showed a minor influence on cell growth. The infected excision wound model indicated that compared to silver-containing activated carbon fiber and other commercial silver-containing dressings assisted wound healing by promoting granulation and collagen deposition. Meanwhile, the silver ion can only be restrained in epidermis by intact skin. During application on the wound area, a temporary increase of serum silver can be detected, but this elevated serum silver level decreased to a subtle level after the removal of silver-containing activated carbon fiber.