Carotid-sinus baroreflex modulation of core and skin temperatures in rats: An open-loop approach
Carotid-sinus baroreflex modulation of core and skin temperatures in rats: An open-loop approach
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DOI：
10.2170/jjphysiol.53.461
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发表时间：
2003-12-01
期刊：
影响因子：
--
通讯作者：
Sato, T
中科院分区：
文献类型：
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作者：
Zhang, DM;Ando, M;Sato, T
神经机制的温度调节控制的核心和皮肤温度的反应，热和冷应力已经很清楚。然而，目前还不清楚压力感受器反射是否参与核心和皮肤温度的控制。为了研究动脉压力感受器反射如何调节体温，我们在氟烷麻醉的大鼠中检测了颈动脉窦压力感受器的压力变化对核心温度和皮肤温度的影响。为了打开压力感受器反射环和控制动脉压力感受器压力（BRP），我们切断迷走神经和主动脉降压神经并分离颈动脉窦。我们依次改变BRP，从60到180 mmHg以20 mmHg的增量，然后从180到60 mmHg以20 mmHg的增量，同时测量主动脉弓处的全身动脉压（SAP）、心率（HR）和核心血液温度（T-core）以及尾部的皮肤温度（T-skin）。随着BRP增加120 mmHg，SAP、HR和T-core分别下降90.3+/-5.1 mmHg、60.3+/-10.5次/分（-1）和0.18+/-0.01 ℃。Tskin上升了0.84+/-0.10 ℃。SAP每单位BRP变化的最大变化率为-2.1+/-0.2，HR为-1.5+/-0.4次/分（-1）mmHg（-1），Tcore为-0.003+/-0.001 ℃ mmHg（-1），T皮肤为0.011+/-0.002 ℃ mmHg（-1）。给药后的六甲铵或溴苄铵，这些压力感受性反射反应完全取消。我们的结论是，Tcore和Tskin调制的动脉压力感受器反射。
The neural mechanisms of the thermoregulatory control of core and skin temperatures in response to heat and cold stresses have been well clarified. However, it has been unclear whether baroreceptor reflexes are involved in the control of core and skin temperatures. To investigate how the arterial baroreceptor reflex modulates the body temperatures, we examined the effect of pressure changes of carotid sinus baroreceptors on core and skin temperatures in halothane-anesthetized rats. To open the barore-flex loop and control arterial baroreceptor pressure (BRP), we cut vagal and aortic depressor nerves and isolated carotid sinuses. We sequentially altered BRP in 20-mmHg increments from 60 to 180 mmHg and then in 20-mmHg decrements from 180 to 60 mmHg while measuring systemic arterial pressure (SAP), heart rate (HR), and core blood temperature (T-core) at the aortic arch and skin temperature (T-skin) at the tail. In response to the incremental change in BRP by 120 mmHg, SAP, HR, and T-core fell by 90.3+/-5.1 mmHg, 60.3+/-10.5 beats min(-1), and 0.18+/-0.01degreesC, respectively. Tskin rose by 0.84+/-0.10degreesC. The maximum rate of change per unit BRP change was -2.1+/-0.2 for SAP, -1.5+/-0.4 beats min(-1) mmHg(-1) for HR, -0.003+/-0.001degreesC mmHg(-1) for Tcore, and 0.011+/-0.002degreesC mmHg(-1) for T-skin. After the administration of hexamethonium or bretylium, these baroreflexogenic responses were completely abolished. We concluded that Tcore and Tskin are modulated by the arterial baroreceptor reflex.