SCHWANN-CELLS INDUCE MORPHOLOGICAL TRANSFORMATION OF SENSORY NEURONS INVITRO
SCHWANN-CELLS INDUCE MORPHOLOGICAL TRANSFORMATION OF SENSORY NEURONS INVITRO
复制标题
DOI：
10.1038/309367a0
复制
发表时间：
1984-01-01
期刊：
影响因子：
64.8
通讯作者：
MUDGE, AW
中科院分区：
文献类型：
--
作者：
MUDGE, AW
细胞与细胞的相互作用被认为在决定脊椎动物细胞的发育命运和调节其随后的分化方面发挥着至关重要的作用。例如，在周围神经系统中，来自神经元轴突的信号决定某些施万细胞是否将其质膜同心地包裹在轴突周围以形成髓鞘1,2。此外，有一些证据表明施万细胞和神经元之间的相互作用并不都是一种方式：例如，施万细胞被认为为神经元萌芽和再生提供信号3-5。然而，目前还没有明确的例子表明施万细胞会影响神经元的正常发育。在这里，我使用纯化的胚胎感觉神经元和施万细胞群来证明施万细胞对这些神经元的发育具有巨大的影响。在雪旺细胞存在但没有其他细胞类型的情况下，感觉神经元经历从不成熟的双极形式到成熟的伪单极形式的形态转变。这提供了一个突出的例子，说明神经胶质细胞对神经元发育的重要性。
Cell–cell interactions are thought to play a crucial part in determining the developmental fate of vertebrate cells and regulating their subsequent differentiation. In the peripheral nervous system, for example, signals from neuronal axons determine whether or not some Schwann cells wrap their plasma membrane concentricially around the axon to form a myelin sheath1,2. Moreover, there is some evidence that the interactions between Schwann cells and neurones are not all one way: for example, Schwann cells are thought to provide signals for neuronal sprouting and regeneration3–5. However, there are no clear examples in which Schwann cells have been shown to influence the normal development of neurones. Here I have used purified populations of embryonic sensory neurones and Schwann cells to demonstrate that Schwann cells have a dramatic influence on the development of these neurones. In the presence of Schwann cells, but not other cell types, the sensory neurones undergo a morphological transformation from an immature bipolar form to a mature pseudo-unipolar form. This provides a striking example of the importance of glial cells for neuronal development.