Diurnal pattern of protein and energy metabolism in man
Diurnal pattern of protein and energy metabolism in man
复制标题
人体蛋白质和能量代谢的昼夜模式
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
J. Waterlow
中科院分区：
文献类型：
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作者：
P. Garlick;G. Clugston;R. W. Swick;J. Waterlow
通过持续静脉输注（I14C）亮氨酸24小时，测量了6名肥胖受试者体内蛋白质的合成和分解率以及亮氨酸的氧化率。夜间不进食时，全身蛋白质合成率是白天每小时进食时的67%。相比之下，体内蛋白质的分解率在整个24小时内保持不变。这导致大约30%的蛋白质在白天立即沉积下来，而剩下的70%立即被氧化。在夜间，蛋白质的氧化率下降到只有白天的38%。在这个时候，氧气消耗的速度也下降了，因此蛋白质氧化对总能量消耗的贡献从白天的27%下降到晚上的13%。这些变化反映了正常的、不连续的食物摄入模式，以及在进食期间需要将蛋白质储存在组织中，以便在随后的禁食期间使用。点。j .中国。核33:1983-1986,1980。
Rates of synthesisand breakdown of body proteinand oxidation of leucine were measured in six obese subjectsby constantintravenousinfusionof (I14C)leucinefor24-hrperiods. During the night,when no food was given,the rateof whole body proteinsynthesiswas 67% of the rateobserved during the day, when food was given hourly.By contrastthe rateof body protein breakdown remained constant over the full 24 hr. This resulted in the immediate deposition of about 30% of the protein intake during the day, whereas the remaining 70% was immediately oxidized. At night the rate of protein oxidation fell to only 38% of its daytime value. The rate of oxygen consumption also decreased at this time so that the contribution of protein oxidation to total energy expenditure fell from 27% during the day to 13% at night. These changes reflect the normal, discontinuous pattern of food intake and the need during feeding to store protein in tissues foruse in subsequent periods of fasting. Am. J. Clin. Nutr. 33: 1983-1986, 1980.