First outbreaks and phylogenetic analyses of avian influenza H9N2 viruses isolated from poultry flocks in Morocco.
First outbreaks and phylogenetic analyses of avian influenza H9N2 viruses isolated from poultry flocks in Morocco.
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DOI：
10.1186/s12985-016-0596-1
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发表时间：
2016-08-15
期刊：
影响因子：
4.8
通讯作者：
Ducatez MF
中科院分区：
文献类型：
--
作者：
El Houadfi M;Fellahi S;Nassik S;Guérin JL;Ducatez MF
H9N2型禽流感病毒继续在世界各地的家禽和野鸟中传播。摩洛哥刚刚面临2016年初影响不同类型家禽生产的第一次H9N2型流感病毒爆发。病毒传入后，在全国范围内迅速传播。从发病率和死亡率较高的11个鸡群中采集样本。从肉鸡中成功分离出4株病毒，从肉鸡中成功分离出1株病毒，并进行了全序列测定。系统发育和分子标记分析表明，摩洛哥病毒属于G1谱系，很可能起源于中东。正如已知的H9N2病毒一样，摩洛哥分离株拥有几个遗传标记，可以增强家禽的毒力并传播给人类。目前的研究表明，在田间条件下，H9N2可能会对鸡蛋产量和死亡率产生破坏性影响，并强调该地区缺乏对病原体的监测数据。
H9N2 avian influenza viruses continue to spread in poultry and wild birds worldwide. Morocco just faced its first H9N2 influenza virus outbreaks early 2016 affecting different types of poultry production. After its introduction, the virus spread very rapidly throughout the country. Samples were collected from 11 chicken flocks with high morbidity and mortality rates. Four viruses were successfully isolated from broiler chickens and one from broiler breeders and fully sequenced. Phylogenetic and molecular markers analyses showed the Moroccan viruses belonged to the G1 lineage and likely originated from the Middle East. As known for H9N2 viruses, the Moroccanisolates possess several genetic markers that enhance virulence in poultry and transmission to humans. The present study demonstrated that under field conditions H9N2 could have a devastating effect on egg production and mortalities and highlighted a lack of surveillance data on the pathogen in the region.