CYSTINE AND THEANINE SUPPLEMENTATION RESTORES HIGH-INTENSITY RESISTANCE EXERCISE-INDUCED ATTENUATION OF NATURAL KILLER CELL ACTIVITY IN WELL-TRAINED MEN
CYSTINE AND THEANINE SUPPLEMENTATION RESTORES HIGH-INTENSITY RESISTANCE EXERCISE-INDUCED ATTENUATION OF NATURAL KILLER CELL ACTIVITY IN WELL-TRAINED MEN
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DOI：
10.1519/jsc.0b013e3181c7c299
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发表时间：
2010-03-01
影响因子：
3.2
通讯作者：
Fukusaki, Chiho
中科院分区：
文献类型：
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作者：
Kawada, Shigeo;Kobayashi, Kando;Fukusaki, Chiho
Kawada，S，小林，K，Ohtani，M，和Jiangusaki，C.补充胱氨酸和茶氨酸可恢复高强度抗阻运动诱导的训练有素男性自然杀伤细胞活性衰减。J Strength Cond Res 24（3）：846-851，2010-我们研究了补充胱氨酸（半胱氨酸的二肽）和茶氨酸（CT）（谷氨酸的前体）对高强度抗阻运动期间免疫变量的影响。半胱氨酸和谷氨酸参与谷胱甘肽的形成，谷胱甘肽调节自然杀伤（NK）细胞的活性。在这项双盲临床试验中，15名训练有素的男性（年龄22.8 ± 4.0岁）被分为2组：安慰剂组（n = 7）和CT组（n = 8）。安慰剂组给予含有纤维素（950 mg）和谷氨酸盐（30 mg）的粉末，而CT组给予含有胱氨酸（700 mg）和茶氨酸（280 mg）的粉末，每天一次，持续2周。受试者在第一周根据他们的正常时间表（每周3次）进行训练，并在第二周以两倍的频率（每周6次）进行训练。免疫球蛋白（IG）M、白细胞介素（IL）-6、IL-8和唾液伊加浓度以及白细胞计数在两组中均无显著变化。有显著下降（p
Kawada, S, Kobayashi, K, Ohtani, M, and Fukusaki, C. Cystine and theanine supplementation restores high-intensity resistance exercise-induced attenuation of natural killer cell activity in well-trained men. J Strength Cond Res 24(3): 846-851, 2010-We investigated the effects of supplementation with cystine, a dipeptide of cysteine, and theanine (CT), a precursor of glutamate, on immune variables during high-intensity resistance exercise. Cysteine and glutamate are involved in the formation of glutathione, which modulates the activity of natural killer (NK) cells. In this double-blinded clinical trial, 15 well-trained men (aged 22.8 +/- 4.0 years) were divided into 2 groups: placebo (n = 7) and CT (n = 8). The placebo group was administered a powder containing cellulose (950 mg) and glutamate (30 mg), whereas the CT group was administered a powder containing cystine (700 mg) and theanine (280 mg), once daily for 2 weeks. The subjects trained according to their normal schedule (3 times per week) in the first week and trained at double the frequency (6 times per week) in the second week. Concentrations of immunoglobulin (Ig)M, interleukin (IL)-6, IL-8, and salivary IgA and the leukocyte count did not change significantly in either group. There was a significant decrease (p