Intra-Golgi Transport: Roles for Vesicles, Tubules, and Cisternae
Intra-Golgi Transport: Roles for Vesicles, Tubules, and Cisternae
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DOI：
10.1155/2013/126731
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发表时间：
2013-02
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影响因子：
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通讯作者：
J. A. Martínez-Menárguez
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文献类型：
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作者：
J. A. Martínez-Menárguez
高尔基复合体被认为是分泌途径的中心站，在这里货物蛋白和脂质被适当地修饰、分类、包装到特定的载体中并被递送到它们的最终目的地。早期的电子显微镜研究显示了这种细胞器非凡的结构复杂性。然而，尽管有大量的传入和传出流量，它能够保持其架构，尽管它也足够灵活，以适应细胞的功能状态。许多参与膜交通和其他高尔基体功能的分子机制的组成部分已被确定。然而，高尔基体功能的一些基本方面仍然没有解决。例如，货物如何通过堆栈移动仍然存在争议，并提出了两个经典的模型：囊泡运输和池成熟。由于这些模型都不能解释所有的实验数据，因此提出了这些模型的组合以及新的模型。在这种情况下，需要澄清的具体作用的池，囊泡和小管。在这篇综述中，我们总结了我们目前的知识高尔基体的组织和功能，专注于内高尔基体运输的机制。
The Golgi complex is considered the central station of the secretory pathway where cargo proteins and lipids are properly modified, classified, packed into specific carriers and delivered to their final destinations. Early electron microscope studies showed the extraordinary structural complexity of this organelle. However, despite the large volume of incoming and outgoing traffic, it is able to maintain its architecture, although it is also flexible enough to adapt to the functional status of the cell. Many components of the molecular machinery involved in membrane traffic and other Golgi functions have been identified. However, some basic aspects of Golgi functioning remain unsolved. For instance, how cargo moves through the stack remains controversial and two classical models have been proposed: vesicular transport and cisternal maturation. Since neither of these models explains all the experimental data, a combination of these models as well as new models have been proposed. In this context, the specific role of the cisternae, vesicles and tubules needs to be clarified. In this review, we summarize our current knowledge of the Golgi organization and function, focusing on the mechanisms of intra-Golgi transport.