Viral Biomarkers in Chronic HBeAg Negative HBV Infection.
Viral Biomarkers in Chronic HBeAg Negative HBV Infection.
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DOI：
10.3390/genes9100469
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发表时间：
2018-09-27
期刊：
影响因子：
3.5
通讯作者：
Laras A
中科院分区：
文献类型：
--
作者：
Hadziyannis E;Laras A
病毒生物标志物是监测慢性B型肝炎病毒（HBV）B型肝炎早期抗原（HBeAg）阴性感染的重要工具，无论是在其自然病程中，还是在治疗期间和治疗后。生物标志物包括针对病毒表位的抗体、病毒蛋白和位于感染肝细胞核中的稳定游离型HBV共价闭合环状DNA（cccDNA）的数量和转录活性的分子替代标志物。血浆或血清中HBV脱氧核糖核酸（DNA）或其他病毒载量的测量是具有重要临床意义的HBV复制标志物。HBV DNA用于国际科学指南中描述的分期和治疗监测。HBV抗原的定量，主要是B肝炎表面抗原（HBsAg）以及B肝炎核心相关抗原（HBcrAg），起着重要但次要的作用，特别是在HBV DNA含量低或检测不到的情况下，并已被评估为非活性携带状态的分类，作为后续HBsAg清除，治疗结果和肝细胞癌（HCC）发展的预测因子。目前正在评估血清中复制中间体HBV RNA的测量，并且也可能被证明是一种重要的生物标志物，特别是在用核苷类似物治疗的患者中。本文综述了上述病毒生物标志物及其在HBV、HBeAg阴性感染中的作用。
Viral biomarkers are important tools for monitoring chronic hepatitis B virus (HBV) hepatitis B early antigen (HBeAg) negative infection, both in its natural course as well as during and after treatment. The biomarkers consist of antibodies against viral epitopes, viral proteins, and molecular surrogate markers of the quantity and transcriptional activity of the stable episomal HBV covalently closed circular DNA (cccDNA) which is located in the nuclei of the infected hepatocytes. HBV deoxyribonucleic acid (DNA) or else viral load measurement in plasma or serum is a marker of HBV replication of major clinical importance. HBV DNA is used for staging and treatment monitoring as described in international scientific guidelines. Quantification of HBV antigens, mainly hepatitis B surface antigen (HBsAg) as well as Hepatitis B core related antigen (HBcrAg), play an important yet secondary role, especially in cases of low or undetectable HBV DNA and has been evaluated for the classification of the inactive carrier state, as a predictor of subsequent HBsAg clearance, treatment outcome, and development of hepatocellular carcinoma (HCC). The measurement of the replicative intermediate HBV RNA in serum is currently evaluated and may also prove to be a significant biomarker particularly in patients treated with nucleot(s)ide analogs. This review focuses on the viral biomarkers mentioned above and their role in HBV, HBeAg negative, infection.
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