The anchoring of glass ceramics of different solubility in the femur of the rat.
The anchoring of glass ceramics of different solubility in the femur of the rat.
复制标题
不同溶解度的玻璃陶瓷在大鼠股骨中的锚定。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
V. Strunz
中科院分区：
文献类型：
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作者：
Ulrich Gross;V. Strunz
富碱生物玻璃或微晶玻璃(45 S 5 A和B，亨奇)或贫碱微晶玻璃(KG S，布劳默)与骨之间的直接物理化学结合已有很好的文献记载。由于长期的研究表明，界面会受到骨的重塑和种植体局部崩解的影响，通过降低Na2O含量并添加Al_2O_3、Ta_2O_5、TiO_2和Sb_2O_3，可以开发出溶解度较低的微晶玻璃。在SD大鼠股骨植入KG S微晶玻璃和不同成分的降低溶解度的微晶玻璃，分别于植入后14、29、30、60、119和245d进行组织学观察。KG S的种植体固定在与骨连接的界面上，可以提供相当大的剪切和拉伸强度；而在溶解度降低的陶瓷界面上，主要观察到软组织、软骨和类骨质。界面上的动态变化表明，软骨细胞向成骨细胞转化和类骨质矿化受到干扰。讨论了在骨愈合或骨再生过程中的这种病理生理过程的干扰。
A direct physicochemical bond between alkali-rich bioglass or glass ceramic (45 S 5 A and B, Hench) or alkali-poor glass ceramic (KG S, Brömer) and bone has been well documented. Since long-term studies have revealed the interface to be subjected to remodeling of the bone and to increased focal disintegration of the implant, glass ceramics of reduced solubility have been developed by lowering the Na2O content and adding Al2O3, Ta2O5, TiO2, and Sb2O3. Implants of glass ceramic KG S and different compositions with reduced solubility have been studied histologically 14, 29, or 30, 60, 119, and 245 days after implantation in the femur of male Sprague-Dawley rats. Implants of KG S are anchored at an interface with bone connection, which is known to provide for application of considerable shear and tensile strengths; whereas, at the interface of ceramics of reduced solubility, soft tissue, chondroid and osteoid are mainly observed. The dynamics of the events at the interface indicate a disturbance of the transformation of chondroid cells into osteoblasts and of the mineralization of osteoid. This disturbance of pathophysiologic processes during bone healing or bone regeneration is discussed.