Translesion Synthesis of 2'-Deoxyguanosine Lesions by Eukaryotic DNA Polymerases.
Translesion Synthesis of 2'-Deoxyguanosine Lesions by Eukaryotic DNA Polymerases.
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DOI：
10.1021/acs.chemrestox.6b00285
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发表时间：
2017-01-17
影响因子：
4.1
通讯作者：
Bose A
中科院分区：
文献类型：
--
作者：
Basu AK;Pande P;Bose A
随着跨损伤合成DNA聚合酶的发现，在过去的二十年里，在理解原核生物和真核生物中各种DNA损伤的复制模式方面取得了很大进展。对数据库的搜索表明，在这一期间发表了大约2 000篇关于这一主题的文章。这包括涉及遗传和结构研究的研究，以及使用纯化的DNA聚合酶和辅助蛋白的体外实验。这是一个艰巨的任务，以了解这一令人兴奋的和迅速新兴的研究领域。尽管如此，由于大多数DNA损伤发生在2′-脱氧鸟苷残基，本观点试图总结这一领域的一个子集，重点是最相关的真核DNA聚合酶负责他们的旁路。
With the discovery of translesion synthesis DNA polymerases, great strides have been made in the last two decades in understanding the mode of replication of various DNA lesions in prokaryotes and eukaryotes. A database search indicated that approximately 2000 articles on this topic have been published in this period. This includes research involving genetic and structural studies as well as in vitro experiments using purified DNA polymerases and accessory proteins. It is a daunting task to comprehend this exciting and rapidly emerging area of research. Even so, as the majority of DNA damage occurs at 2′-deoxyguanosine residues, this perspective attempts to summarize a subset of this field, focusing on the most relevant eukaryotic DNA polymerases responsible for their bypass.