The redox protein construction kit: pre-last universal common ancestor evolution of energy-conserving enzymes
The redox protein construction kit: pre-last universal common ancestor evolution of energy-conserving enzymes
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DOI：
10.1098/rstb.2002.1184
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发表时间：
2003-01-29
期刊：
影响因子：
--
通讯作者：
Nitschke, W
中科院分区：
文献类型：
--
作者：
Baymann, F;Lebrun, E;Nitschke, W
近年来，基因组分析和三维结构的解析为参与生物能电子传递的多种酶的氧化还原蛋白之间迄今为止意想不到的家族关系提供了证据。事实上，许多酶似乎仅由一组有限的结构单元构成。对这个“氧化还原酶构建套件”中选定单元的系统发育分析表明，几种重要的生物能酶的起源非常早，位于细菌和古细菌的分化之前。根据获得的树拓扑结构，提出了所选复合体早期演化的可能场景。
Genome analyses and the resolution of three-dimensional structures have provided evidence in recent years for hitherto unexpected family relationships between redox proteins of very diverse enzymes involved in bioenergetic electron transport. Many of these enzymes appear in fact to be constructed from only a limited set of building blocks. Phylogenetic analysis of selected units from this 'redox enzyme construction kit' indicates an origin for several prominent bioenergetic enzymes that is very early, lying before the divergence of Bacteria and Archaea. Possible scenarios for the early evolution of selected complexes are proposed based on the obtained tree topologies.