Use of allogeneic NK cells for cancer immunotherapy.
Use of allogeneic NK cells for cancer immunotherapy.
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DOI：
10.2217/imt.11.131
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发表时间：
2011-12
期刊：
影响因子：
2.8
通讯作者：
Miller JS
中科院分区：
文献类型：
--
作者：
Geller MA;Miller JS
关于免疫系统在癌症治疗中发挥的作用存在争议。虽然免疫系统被认为可以清除身体以防止微观转化形成癌症，但很难发挥其缩小已形成肿瘤的潜力。 NK 细胞是先天免疫系统的组成部分。它们可以在没有事先致敏的情况下识别靶标，这使它们成为用于治疗癌症的理想候选者。最初，自体 NK 细胞针对肿瘤，但人们意识到识别自身细胞的 NK 细胞会受到抑制。同种异体 NK 细胞疗法在临床试验中取得了更令人鼓舞的进展，以克服这一限制。在本文中，我们介绍了 NK 细胞过继免疫疗法治疗血液和实体瘤恶性肿瘤的进展。
Controversy exists as to the role that the immune system plays in cancer therapy. While the immune system has been proposed to scavenge the body to prevent microscopic transformation from forming cancer, it has been difficult to mount its potential of shrinking established tumors. NK cells are components of the innate immune system. They can recognize targets without prior sensitization, making them ideal candidates to manipulate for therapeutic use against cancer. Initially, autologous NK cells were directed against tumors but it was realized that NK cells that recognize self cells are inhibited. More encouraging advances have been made with allogeneic NK cell therapy in clinical trials to overcome this limitation. In this article, we present developments in NK cell adoptive immunotherapy for hematologic and solid tumor malignancies.
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影响因子：
11.2
作者：
Carlsten, Mattias;Bjorkstrom, Niklas K.;Malmberg, Karl Johan
通讯作者：
Malmberg, Karl Johan
影响因子：
20.3
作者：
Bryceson, YT;March, ME;Long, EO
通讯作者：
Long, EO
影响因子：
45.3
作者：
Bibeau, Frederic;Lopez-Crapez, Evelyne;Boissiere-Michot, Florence
通讯作者：
Boissiere-Michot, Florence
影响因子：
105.7
作者：
BURNET, M
通讯作者：
BURNET, M
DOI：
10.1073/pnas.0509249103
发表时间：
2006-04-04
影响因子：
11.1
作者：
Barao, I;Hanash, AM;Murphy, WJ
通讯作者：
Murphy, WJ