Supercritical fluid assisted production of chitosan oligomers micrometric powders.
Supercritical fluid assisted production of chitosan oligomers micrometric powders.
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DOI：
10.1016/j.carbpol.2013.11.029
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发表时间：
2014-02
影响因子：
11.2
通讯作者：
Zhe Du;Yu-Bin Shen;Chuan Tang;Y. Guan;Shanjing Yao;Ziqiang Zhu
中科院分区：
文献类型：
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作者：
Zhe Du;Yu-Bin Shen;Chuan Tang;Y. Guan;Shanjing Yao;Ziqiang Zhu
采用水力空化混合器（SAA HCM）引入超临界流体辅助雾化技术，从水溶液中制备了壳聚糖低聚物（O-chitosan）微粒。流体动力空化的引入，以加强传质和促进SC-CO2和液体溶液之间的混合，以形成细颗粒。得到了轮廓清晰、分离、呈球形的微粒，粒径可以很好地控制，分布范围较窄，为0.5 μm ~ 3 μm。XRD图谱显示O-壳聚糖微粒为无定形结构。FTIR、TGA和DSC分析证实，SAA-HCM处理后，分子结构和热稳定性没有变化，而水含量在5.8%~ 8.4%之间。最后，振实密度测定为低于0.45 g/cm 3，表明微粒的中空或多孔结构。通过调整工艺参数，制备的O-壳聚糖微粒的理论质量中值空气动力学粒径在1-2 μm范围内，有望作为吸入干粉应用。SAA-HCM被证明是非常有用的粒度工程。
Chitosan oligomers (O-chitosan) micrometric particles were produced from aqueous solution using a novel process, i.e. supercritical fluid assisted atomization introduced by hydrodynamic cavitation mixer (SAA-HCM). Hydrodynamic cavitation was introduced to enhance mass transfer and facilitate the mixing between SC-CO2and liquid solution for fine particles formation. Well defined, separated and spherical microparticles were obtained, and the particles size could be well controlled with narrow distribution ranging from 0.5 μm to 3 μm. XRD patterns showed amorphous structure of O-chitosan microparticles. FTIR, TGA and DSC analyses confirmed that no change in molecular structure and thermal stability after SAA-HCM processing, while the water content was between 5.8% and 8.4%. Finally, tap densities were determined to be below 0.45 g/cm3indicating hollow or porous structures of microparticles. By tuning process parameters, theoretical mass median aerodynamic sizes lied inside respirable range of 1–2 μm, which presented the potential of the O-chitosan microparticles in application as inhaled dry powders. SAA-HCM was demonstrated to be very useful in particle size engineering.