CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1-infected individuals
CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1-infected individuals
复制标题
DOI：
10.1038/nm1741
复制
发表时间：
2008-04-01
期刊：
影响因子：
82.9
通讯作者：
Dolan, Matthew J.
中科院分区：
文献类型：
--
作者：
Ahuja, Sunil K.;Kulkarni, Hemant;Dolan, Matthew J.
在接受高效抗逆转录病毒治疗 (HAART) 的 HIV 感染者中，CD4(+) T 细胞计数重建中出现广泛变异的基础尚不完全清楚。在这里，我们表明，CCL3L1 基因剂量和 CCR5 基因型的变化，但不是主要组织相容性复合体 HLA 等位基因的变化，影响免疫重建，特别是当 HAART 开始于
The basis for the extensive variability seen in the reconstitution of CD4(+) T cell counts in HIV- infected individuals receiving highly active antiretroviral therapy ( HAART) is not fully known. Here, we show that variations in CCL3L1 gene dose and CCR5 genotype, but not major histocompatibility complex HLA alleles, influence immune reconstitution, especially when HAART is initiated at