HEMOSTATIC EFFECTIVENESS OF PLATELETS STORED AT 22 DEGREES C
HEMOSTATIC EFFECTIVENESS OF PLATELETS STORED AT 22 DEGREES C
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DOI：
10.1056/nejm197109022851003
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发表时间：
1971-01-01
影响因子：
158.5
通讯作者：
VALERI, CR
中科院分区：
文献类型：
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作者：
HANDIN, RI;VALERI, CR
将血小板保存在22℃而不是4°C可提高51Cr回收率和血小板寿命测量。为了延长出血时间和抑制血小板聚集，对正常志愿者输注阿司匹林后的血小板功能状态进行了研究。输注相当于总血小板10%以上的新鲜血小板，可立即缩短出血时间，并使血小板聚集模式恢复正常。22℃袋装保存24~48小时的血小板，在24小时内，出血时间和聚集模式均恢复正常。在给服用阿司匹林的志愿者输血后，观察到他们恢复了正常的聚集状态，这表明输血后血小板功能有所改善。22℃保存24小时的血小板比22℃保存48小时的血小板更容易恢复体内的正常聚集。
Storage of platelets at 22 rather than 4°C improves both51Cr recovery and platelet life-span measurements. The functional state of such platelets after transfusion was studied in normal volunteers treated with aspirin to prolong bleeding time and impair platelet aggregation. Transfusion of fresh platelets to equal more than 10 per cent of the total immediately shortened the bleeding time and restored the platelet aggregation patterns to normal. The aggregation patterns of platelets deteriorated during storage in bags at 22°C. Within 24 hours after transfusion of platelets previously stored for 24 to 48 hours at 22°C, both bleeding time and aggregation patterns were restored toward normal. The observation that after transfusion to aspirin-treated volunteers normal aggregation returned suggests improvement in platelet function after transfusion. Return of normal aggregation in vivo was better for platelets stored at 22°C for only 24 hours than for platelets stored at 22°C for 48 hours.