Pentraxin 3 Is a New Inflammatory Marker Correlated With Left Ventricular Diastolic Dysfunction and Heart Failure With Normal Ejection Fraction
Pentraxin 3 Is a New Inflammatory Marker Correlated With Left Ventricular Diastolic Dysfunction and Heart Failure With Normal Ejection Fraction
复制标题
DOI：
10.1016/j.jacc.2010.10.018
复制
发表时间：
2011-02-15
影响因子：
24
通讯作者：
Ogawa, Hisao
中科院分区：
文献类型：
--
作者：
Matsubara, Junichi;Sugiyama, Seigo;Ogawa, Hisao
目的探讨射血分数正常的心力衰竭（HFNEF）患者血浆正五聚蛋白3（Pentraxin 3，PTX 3）水平的临床意义以及PTX 3是否来源于冠状动脉循环。炎症标志物和HFNEF. Methods之间的关系仍然不清楚，我们测量了323例患者的外周血水平的PTX 3，高敏CRP，肿瘤坏死因子-α，白细胞介素-6，82 HFNEF，70心力衰竭（HF）EF降低，和171非HF患者。结果HFNEF患者的PTX 3、TNF-α和IL-6水平显著高于非HF患者，而高敏CRP水平则无显著性差异。多变量逻辑回归分析仅将高水平的PTX 3确定为与左心室（LV）EF正常的患者中HFNEF存在相关的独立炎症标志物（比值比[OR]：1.49，95%置信区间[CI]：1.11至1.98，p < 0.01），非HF患者中存在左心室舒张功能障碍（LVDD）（或：1.23，95%CI：1.02至1.50，p < 0.05）。HFNEF患者冠状静脉窦PTX 3水平显著高于主动脉根部（p < 0.05），非HF合并LVDD患者冠状静脉窦PTX 3水平显著高于主动脉根部（p < 0.01），而非HF合并LVDD患者冠状静脉窦PTX 3水平与主动脉根部无显著差异（p = 0.33）。正五聚蛋白3是与LVDD和HFNEF相关的独立炎症标志物，而不是高敏CRP。(The舒张性心力衰竭患者血浆正五聚蛋白3水平的临床意义; UMIN 000002170）（J Am科尔心脏病学杂志2011; 57：861-9）（C）2011年，美国心脏病学会基金会
Objectives This study investigated the clinical significance of plasma pentraxin 3 (PTX3) levels in patients with heart failure with normal ejection fraction (HFNEF) and whether PTX3 is produced from coronary circulation.Background Pentraxin 3 is a novel inflammatory marker and a member of pentraxin superfamily including C-reactive protein (CRP). The relationship between inflammatory markers and HFNEF remains unclear.Methods We measured peripheral blood levels of PTX3, high-sensitivity CRP, tumor necrosis factor-alpha, and interleukin-6 in 323 patients comprising 82 HFNEF, 70 heart failure (HF) with reduced EF, and 171 non-HF patients. Levels of PTX3 were also measured at the aortic root and the coronary sinus in 75 patients.Results The levels of PTX3, tumor necrosis factor-alpha, and interleukin-6, but not high-sensitivity CRP, were significantly higher in HFNEF patients than in non-HF patients. Multivariate logistic regression analysis identified only high levels of PTX3 as the independent inflammatory marker correlated with the presence of HFNEF in patients with normal left ventricular (LV) EF (odds ratio [OR]: 1.49, 95% confidence interval [CI]: 1.11 to 1.98, p < 0.01) and with the presence of left ventricular diastolic dysfunction (LVDD) in non-HF patients (OR: 1.23, 95% CI: 1.02 to 1.50, p < 0.05). Levels of PTX3 at the coronary sinus were significantly higher than at the aortic root in HFNEF patients (p < 0.05) and in non-HF patients with LVDD (p < 0.01), but not different in non-HF patients without LVDD (p = 0.33).Conclusions Pentraxin 3 is significantly elevated in HFNEF patients and produced in the coronary circulation in patients with LVDD. Pentraxin 3, but not high-sensitivity CRP, is an independent inflammatory marker correlated with the presence of LVDD and HFNEF. (The Clinical Significance of Plasma Pentraxin 3 levels for Patients with Diastolic Heart Failure; UMIN000002170) (J Am Coll Cardiol 2011; 57: 861-9) (C) 2011 by the American College of Cardiology Foundation