Sphingosine's role in epithelial host defense: A natural antimicrobial and novel therapeutic
Sphingosine's role in epithelial host defense: A natural antimicrobial and novel therapeutic
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DOI：
10.1016/j.biochi.2017.03.014
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发表时间：
2017-10-01
期刊：
影响因子：
3.9
通讯作者：
Seitz, Aaron
中科院分区：
文献类型：
--
作者：
Martin, Grace E.;Boudreau, Ryan M.;Seitz, Aaron
鞘氨醇是在所有真核细胞的膜中发现的天然鞘脂。除了其在细胞信号传导中的功能外，鞘氨醇还具有广谱抗菌特性。鞘氨醇作为抗菌剂的作用在皮肤和呼吸道上皮等组织中很重要。正常鞘氨醇水平的降低与感染易感性相关的问题有关。因此，外源性鞘氨醇可能是一种有效的抗菌治疗剂。在多种小鼠模型中，吸入雾化鞘氨醇已被证明可有效预防和治疗肺炎。我们现在表明，吸入鞘氨醇对呼吸系统的毒性低，加强了其作为一种新型吸入抗菌药物的优秀候选者的情况。(C)2017 Elsevier B.V.和Societe Francaise de Biochimie et Biologie Moleculaire（SFBBM）。All rights reserved.
Sphingosine is a natural sphingolipid found in membranes of all eukaryotic cells. In addition to its functions in cell signaling, sphingosine has broad-spectrum antimicrobial properties. Sphingosine's role as an antimicrobial is important in tissues such as the skin and respiratory epithelium. Reduction in the normal sphingosine level is associated with problems related to infection susceptibility. Therefore, exogenous sphingosine may be an effective antimicrobial therapeutic. Inhaled nebulized sphingosine has been shown to be effective at both preventing and treating pneumonia in multiple mouse models. We now show that inhaled sphingosine has low toxicity to the respiratory system, strengthening its case as an excellent candidate for a novel inhaled antimicrobial drug. (C) 2017 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.