Risk factors and clinical manifestations of pathologically verified lacunar infarctions.
Risk factors and clinical manifestations of pathologically verified lacunar infarctions.
复制标题
经病理证实的腔隙性梗死的危险因素和临床表现。
作者：
Tuszynski,MH;Petito,CK;Levy,DE
对 2,859 份尸检报告的审查显示，169 名患者 (6%) 患有腔隙性梗死。对其中 167 名患者的图表进行审查后发现，64% 的患者患有高血压，34% 的患者患有糖尿病，46% 的患者患有吸烟，18% 的患者没有已知的脑血管疾病危险因素。多达81%的腔隙患者没有症状。有症状的腔隙性病变最常见的表现为单纯运动偏瘫（31%）、失语加右侧偏瘫（20%）或感觉运动功能障碍（11%）；没有一个表现为纯粹的感觉中风。这些结果表明，腔隙性梗塞的谱系比以前认为的更加异质。大多数腔隙是无症状的，并且大多数有症状的患者并不表现出“经典”腔隙综合征。
Review of 2,859 autopsy reports disclosed lacunar infarctions in 169 patients (6%). Review of the charts of 167 of these patients revealed hypertension in 64%, diabetes in 34%, smoking in 46%, and no known risk factor for cerebrovascular disease in 18%. As many as 81% of the patients with lacunes were asymptomatic. Symptomatic lacunes presented most commonly as pure motor hemiparesis (31%), aphasia plus right hemiparesis (20%), or sensorimotor dysfunction (11%); none presented as pure sensory stroke. These results suggest that the spectrum of lacunar infarction is more heterogeneous than previously thought. Most lacunes are asymptomatic, and the majority of symptomatic patients do not present with "classical" lacunar syndromes.