Positive correlation between Epstein-Barr virus viral load and anti-viral capsid immunoglobulin G titers determined for Hodgkin's lymphoma patients and their relatives
Positive correlation between Epstein-Barr virus viral load and anti-viral capsid immunoglobulin G titers determined for Hodgkin's lymphoma patients and their relatives
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DOI：
10.1128/jcm.44.1.47-50.2006
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发表时间：
2006-01-01
影响因子：
9.4
通讯作者：
Nicolas, JC
中科院分区：
文献类型：
--
作者：
Besson, C;Amiel, C;Nicolas, JC
EB病毒（EBV）感染的标志物包括特定血清学滴度和外周血单核细胞中病毒载量（VLo）的测量。很少有研究调查这两种表型之间的相关性。在此，我们发现VLo与抗EBV核抗原I型或抗早期抗原免疫球蛋白G（IgG）滴度无相关性，但霍奇金淋巴瘤患者外周血单个核细胞中抗病毒衣壳抗原（VCA）IgG滴度随VLo升高而升高（P = 3.10（-3））。在患者的健康一级亲属（父母和兄弟姐妹）中观察到类似的模式（P = 6.10（-4））。我们的研究结果表明，抗VCA IgG滴度和EBV VLo特异性相关的EBV表型。
Markers of Epstein-Barr virus (EBV) infection include measures of specific serological titers and of viral load (VLo) in peripheral blood mononuclear cells. Few studies have investigated the correlation between these two phenotypes. Here, we found that there was no correlation between VLo and either anti-EBV nuclear antigen type I or anti-early antigen immunoglobulin G (IgG) titer but that anti-viral capsid antigen (VCA) IgG titer increased with VLo in peripheral blood mononuclear cells in patients with Hodgkin's lymphoma (P = 3.10(-3)). A similar pattern was observed in healthy first-degree relatives (parents and siblings) of patients (P = 6.10(-4)). Our results indicate that anti-VCA IgG titers and EBV VLo are specifically correlated EBV phenotypes.