RELATION OF AGE TO DURATION OF CONTRACTION EJECTION + RELAXATION OF NORMAL HUMAN HEART
RELATION OF AGE TO DURATION OF CONTRACTION EJECTION + RELAXATION OF NORMAL HUMAN HEART
复制标题
DOI：
10.1016/0002-8703(64)90370-9
复制
发表时间：
1964-01-01
影响因子：
4.8
通讯作者：
DIXON, K
中科院分区：
文献类型：
--
作者：
HARRISON, TR;COLEMAN, HN;DIXON, K
对健康人随年龄增长的主要观察结果如下：（1）射血期逐渐延长，表明射血末期和射血初期的脉搏传导时间相同。因此，颈动脉上行-颈动脉切迹间期似乎是一个可靠的指导射血持续时间。(3)校正心率后，射血持续时间无显著变化。(4)兴奋-颈动脉上搏间期轻微缩短。然而，激发-喷射时间（即，结果表明：（1）舒张期的延长可能是老年正常心脏相对不能耐受心动过速的一个重要因素。粗略计算表明，平均而言，70岁以上的人不能忍受120或更高的持续心率。(b)引发压力、维持压力和松弛的基本机制似乎是独立变化的，这些发现和结论是基于间接方法获得的数据。在通过更精确的技术加以证实（或反驳）之前，它们应被视为进一步研究的出发点，而不是既定的概念。
The chief findings in healthy persons with advancing age were as follows: (1) Progressive prolongation of the period of dicates that the pulse transmission time is the same at the end as at the beginning of ejection. Thus, the carotid upstroke-carotid incisura interval appears to be a reliable guide to the duration of ejection. (3) No significant change in the duration of ejection when corrected for heart rate. (4) Slight reduction in the excitation-carotid upstroke interval. However, the excitation-ejection time (i.e., the excitation-carotid upstroke interval corrected for pulse transmission time) tended to lengthen slightly with advancing age.The findings have led to the following tentative conclusions: (a) The prolongation of relaxation may be a factor of some importance in regard to the relative inability of old normal hearts to tolerate tachycardia. Rough calculations suggest that, as an average, a sustained rate of 120, or more, cannot be tolerated beyond the age of 70. (b) The basic mechanisms responsible for initiating pressure, for sustaining pressure, and for relaxation appear to vary independently.These findings and conclusions are based on data secured by indirect methods. Pending confirmation (or refutation) by more precise techniques, they should be considered as points of departure for further studies rather than as established concepts.