Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology.
Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology.
复制标题
在合成生物学时代，用于癌症免疫疗法的过继T细胞转移。
DOI：
10.1016/j.immuni.2013.07.002
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发表时间：
2013-07-25
期刊：
影响因子：
32.4
通讯作者：
June CH
中科院分区：
文献类型：
--
作者：
Kalos M;June CH
用于癌症和慢性感染的过继T细胞转移是一个新兴领域，在最近的试验中显示出了希望。基于合成生物学的T淋巴细胞工程表达高亲和力抗原受体可以克服免疫耐受，这已经成为基于免疫治疗的策略的主要限制。细胞工程和培养方法的进步，使高效的基因转移和体外细胞扩增促进了对这项技术的更广泛评估，使采用转移从“精品”应用程序变成了主流技术的尖端。目前该领域面临的主要挑战是提高工程T细胞对肿瘤的特异性，因为最近的试验观察到，靶向共同抗原有可能导致靶向上的肿瘤外毒性。随着采用转移技术领域的成熟，主要的工程挑战是自动化细胞培养系统的开发，以便该方法可以扩展到专门的学术中心并得到广泛应用。
Adoptive T cell transfer for cancer and chronic infection is an emerging field that shows promise in recent trials. Synthetic biology-based engineering of T lymphocytes to express high affinity antigen-receptors can overcome immune tolerance, which has been a major limitation of immunotherapy-based strategies. Advances in cell engineering and culture approaches to enable efficient gene transfer and ex vivo cell expansion have facilitated broader evaluation of this technology, moving adoptive transfer from a “boutique” application to the cusp of a mainstream technology. The major challenge currently facing the field is to increase the specificity of engineered T cells for tumors, since targeting shared antigens has the potential to lead to on-target off-tumor toxicities, as observed in recent trials. As the field of adoptive transfer technology matures, the major engineering challenge is the development of automated cell culture systems, so that the approach can extend beyond specialized academic centers and become widely available.
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