Lysophosphatidic acid in neural signaling.
Lysophosphatidic acid in neural signaling.
复制标题
神经信号传导中的溶血磷脂酸。
作者：
X. Ye;N. Fukushima;Marcy A. Kingsbury;J. Chun
溶血磷脂酸(LPA)的存在及其受体在神经组织中的表达，突显了LPA在神经系统中的生理和病理意义。事实上，LPA在与神经系统功能相关的多种细胞类型中产生反应。这些细胞类型包括神经细胞系、神经前体细胞、原代神经元、少突胶质细胞、雪旺细胞、星形胶质细胞、小胶质细胞和脑内皮细胞。LPA诱导的细胞类型特异性效应包括改变细胞形态、促进细胞增殖和存活、诱导细胞死亡、改变离子电导和钙动员、诱导疼痛传递和刺激血管收缩。这些作用是通过一些G蛋白偶联的LPA受体来介导的，这些受体激活了各种下游的信号级联反应。本文结合我们目前对LPA在神经细胞中诱导效应的信号通路的了解，对LPA在体外或体内诱导神经细胞的效应进行了综述。
The physiological and pathological importance of lysophosphatidic acid (LPA) in the nervous system is underscored by its presence, as well as the expression of its receptors in neural tissues. In fact, LPA produces responses in a broad range of cell types related to the function of the nervous system. These cell types include neural cell lines, neural progenitors, primary neurons, oligodendrocytes, Schwann cells, astrocytes, microglia, and brain endothelial cells. LPA-induced cell type-specific effects include changes in cell morphology, promotion of cell proliferation and cell survival, induction of cell death, changes in ion conductance and Ca2+ mobilization, induction of pain transmission, and stimulation of vasoconstriction. These effects are mediated through a number of G protein-coupled LPA receptors that activate various downstream signaling cascades. This review provides a current summary of LPA-induced effects in neural cells in vitro or in vivo in combination with our current understanding of the signaling pathways responsible for these effects.