p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China.
p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China.
复制标题
DOI：
--
复制
发表时间：
1992-03
期刊：
影响因子：
11.2
通讯作者：
Kathleen A. Scorsone;Yi-zhong Zhou;J. Butel;B. Slagle
中科院分区：
文献类型：
--
作者：
Kathleen A. Scorsone;Yi-zhong Zhou;J. Butel;B. Slagle
对36例中国原发性肝细胞癌（HCC）患者的DNA样本进行了p53基因249密码子特异性突变筛查，该突变是最近在一些HCC中发现的热点突变。我们在36例肝癌中检测到21例（58%）肿瘤特异性p53密码子249突变。13名具有特定密码子249突变的患者丢失了p53的剩余等位基因，而其余8名患者似乎保留了该基因的两个拷贝。这些结果提示p53基因的改变可能是HCC发生的重要事件，点突变可能先于等位基因丢失。
DNA samples from 36 hepatocellular carcinoma (HCC) patients from China were screened for a specific mutation affecting codon 249 of the p53 gene, recently identified as a hotspot mutation in some HCCs. We detected the tumor-specific p53 codon 249 mutation in 21 (58%) of 36 HCCs examined. Thirteen patients with the specific codon 249 mutation had lost the remaining allele of p53, whereas the remaining eight patients appeared to have retained both copies of the gene. These results suggest that alterations of p53 may be important events in the genesis of HCCs and that point mutation may precede allele loss.