Methods for evaluation of medication adherence and persistence using automated databases
Methods for evaluation of medication adherence and persistence using automated databases
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DOI：
10.1002/pds.1230
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发表时间：
2006-08-01
影响因子：
2.6
通讯作者：
Chan, K. Arnold
中科院分区：
文献类型：
--
作者：
Andrade, Susan E.;Kahler, Kristijan H.;Chan, K. Arnold
目的我们的目的是进行一个系统的评价方法，目前正在使用的药物流行病学和药物经济学研究的依从性和持久性，使用自动databases.Methods的英文文献进行检索，以确定1980年1月1日和2004年3月31日之间发表的研究，评价依从性，依从性，持久性，转换，或使用自动配药数据（药房记录）停止药物。两名研究者独立审查的摘要和文章，以确定相关的研究根据指定的critics.Results共136篇文章符合标准的评价。通常报告的依从性和持续性指标的类型包括药物拥有率和药物可用性（77项研究）、停药/继续（58项研究）、转换（34项研究）、药物缺口（13项研究）、补充依从性（7项研究）和保留/动荡（4项研究）的相关指标。考虑的具体问题包括评估暴露时间的药物治疗和规格的随访period.Conclusions的术语，定义和方法，以确定遵守和持久性在已发表的文献中有很大的不同。所采用的具体措施的适当性和选择应取决于研究的总体目标以及措施的相对优势和局限性。版权所有（c）2006约翰威利父子有限公司。
Purpose Our aim was to perform a systematic review of the methods currently being used to assess adherence and persistence in pharmacoepidemiological and pharmacoeconomic studies using automated databases.Methods A MEDLINE search of English language literature was performed to identify studies published between January 1, 1980 and March 31, 2004 that evaluated adherence, compliance, persistence, switching, or discontinuations of medications using automated dispensing data (pharmacy records). Two study investigators independently reviewed the abstracts and articles to determine relevant studies according to specified criteria.Results A total of 136 articles met the criteria for evaluation. The types of measures of adherence and persistence commonly reported include the medication possession ratio and related measures of medication availability (77 studies), discontinuation/continuation (58 studies), switching (34 studies), medication gaps (13 studies), refill compliance (7 studies), and retentiveness/turbulence (4 studies). Specific issues considered include the assessment of exposed time to drug therapy and specification of the follow-up period.Conclusions The terminology, definitions, and methods to determine adherence and persistence differ greatly in the published literature. The appropriateness and choice of the specific measure employed should be determined by the overall goals of the study, as well as the relative advantages and limitations of the measures. Copyright (c) 2006 John Wiley & Sons, Ltd.