Synthesis and characterization of new pyrimidine-based 1,3,4-oxa(thia)diazoles, 1,2,4-triazoles and 4-thiazolidinones
Synthesis and characterization of new pyrimidine-based 1,3,4-oxa(thia)diazoles, 1,2,4-triazoles and 4-thiazolidinones
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DOI：
10.3998/ark.5550190.0010.c24
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发表时间：
2009-01-01
期刊：
影响因子：
0.9
通讯作者：
Vainilavicius, Povilas
中科院分区：
文献类型：
--
作者：
Burbuliene, Milda M.;Sakociute, Vaida;Vainilavicius, Povilas
通过N-取代的2-[2-(6-甲基-2-吗啉代嘧啶-4-基硫基)环化合成新的1,2,4-三唑3a,b、4a,b、1,3,4-恶二唑5a,b、1,3,4-噻二唑6a,b和4-噻唑烷酮7a,b不同条件下的乙酰基]肼硫代碳酰胺2a,b。通过用异硫氰酸环己酯或异硫氰酸苯酯酰化2-(6-甲基-2-吗啉代嘧啶-4-基硫基)乙酰酰肼(1)容易获得起始2a、b。所有新化合物均通过 H-1、C-13 NMR、IR 光谱和元素分析进行了表征。
New 1,2,4-triazoles 3a,b, 4a,b, 1,3,4-oxadiazoles 5a,b, 1,3,4-thiadiazoles 6a,b and 4-thiazolidinones 7a,b were synthesized by cyclization of N-substituted 2-[2-(6-methyl-2-morpholinopyrimidin-4-ylthio) acetyl]hydrazinecarbothioamides 2a,b under different conditions. The starting 2a, b were readily obtained by acylation of 2-(6-methyl-2-morpholinopyrimidin-4-ylthio)acetohydrazide (1) with cyclohexyl or phenyl isothiocyanate. All new compounds were characterized by H-1, C-13 NMR, IR spectroscopy and elemental analysis.