ELECTROMYOGRAPHIC AND NERVE-CONDUCTION STUDIES IN THE MDX MOUSE
ELECTROMYOGRAPHIC AND NERVE-CONDUCTION STUDIES IN THE MDX MOUSE
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DOI：
10.1097/00002060-199202000-00002
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发表时间：
1992-02-01
影响因子：
3
通讯作者：
ENTRIKIN, RK
中科院分区：
文献类型：
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作者：
CARTER, GT;LONGLEY, KJ;ENTRIKIN, RK
在20-154天，记录正常和营养不良（mdx）小鼠腓肠肌、比目鱼肌和胫骨前肌对针电极插入和重复间接刺激的肌电反应。 来自肌强直（ADR（mto））小鼠的记录用作“真正”肌强直的对照。 在mdx小鼠的肌肉中观察到复杂重复放电，但在正常对照小鼠的肌肉中未观察到复杂重复放电或其他异常。 mdx肌肉中复杂的重复放电与强直性肌强直小鼠肌肉中观察到的延长的异常重复放电不同。 筒箭毒碱神经肌肉阻滞和神经切断对观察到的mdx小鼠肌电图异常没有影响。 神经传导和重复刺激研究也显示mdx小鼠无异常。 这些发现表明mdx是一种非强直性的原发性肌病。 在mdx小鼠中没有发现肌强直或神经肌肉传递受损的迹象。
Electromyographic responses to needle-electrode insertion and repetitive indirect stimulation were recorded from gastrocnemius, soleus and cranial tibialis muscles of normal and dystrophic (mdx) mice at 20-154 days. Recordings from myotonic (ADR(mto)) mice served as controls for "true" myotonia. Complex repetitive discharges were observed in muscles of mdx mice but no complex repetitive discharges or other abnormalities were observed in muscles of normal control mice. Complex repetitive discharges in mdx muscles did not resemble the prolonged, abnormally repetitive discharges observed in myotonic mouse muscles. Neuromuscular blockade with tubocurarine and nerve transection had no effect on observed electromyographic abnormalities in the mdx mice. Nerve conduction and repetitive stimulation studies also revealed no abnormalities in mdx mice. These findings indicate that the mdx condition is a nonmyotonic, primary myopathy. No signs of myotonia or impaired neuromuscular transmission were found in mdx mice.