The translocation t(8;l6)(p11, p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB binding protein
The translocation t(8;l6)(p11, p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB binding protein
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DOI：
10.1038/ng0996-33
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发表时间：
1996-09-01
期刊：
影响因子：
30.8
通讯作者：
Housman, DE
中科院分区：
文献类型：
--
作者：
Borrow, J;Stanton, VP;Housman, DE
反复易位t(8；16)(p11；p13)是M4/M5亚型急性髓系白血病的细胞遗传学标志。在这里，我们识别断点相关基因。16号染色体上的定位克隆涉及CREB结合蛋白(CBP)，这是一种转录适配/辅助激活蛋白。在8号染色体的断裂点，我们发现了一个新的基因moz，它编码一个2,004氨基酸的蛋白质，其特征是两个C4HC3锌指和一个C2HC锌指以及一个可能的乙酰转移酶特征。框内MoZ-CBP融合转录本结合了MoZ手指基序和推测的乙酰基转移酶结构域，具有基本完整的CBP。我们认为，MOZ可能代表染色质相关的乙酰转移酶，并增加了一个主要的MoZ-CBP融合蛋白可能通过异常的染色质乙酰化来介导白血病发生的可能性。
The recurrent translocation t(8;16)(p11;p13) is a cytogenetic hallmark for the M4/M5 subtype of acute myeloid leukaemia. Here we identify the breakpoint-associated genes. Positional cloning on chromosome 16 implicates the CREB-binding protein (CBP), a transcriptional adaptor/coactivator protein. At the chromosome 8 breakpoint we identify a novel gene, MOZ, which encodes a 2,004-amino-acid protein characterized by two C4HC3 zinc fingers and a single C2HC zinc finger in conjunction with a putative acetyltransferase signature. In-frame MOZ-CBP fusion transcripts combine the MOZ finger motifs and putative acetyltransferase domain with a largely intact CBP. We suggest that MOZ may represent a chromatin-associated acetyltransferase, and raise the possibility that a dominant MOZ-CBP fusion protein could mediate leukaemogenesis via aberrant chromatin acetylation.