BACTERIAL-INFECTION (LEGIONELLA-PNEUMOPHILA) STIMULATES FEVER, METABOLIC-RATE AND BROWN ADIPOSE-TISSUE ACTIVITY IN THE GUINEA-PIG
BACTERIAL-INFECTION (LEGIONELLA-PNEUMOPHILA) STIMULATES FEVER, METABOLIC-RATE AND BROWN ADIPOSE-TISSUE ACTIVITY IN THE GUINEA-PIG
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DOI：
10.1016/0024-3205(89)90178-1
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发表时间：
1989-01-01
期刊：
影响因子：
6.1
通讯作者：
ROTHWELL, NJ
中科院分区：
文献类型：
--
作者：
COOPER, AL;FITZGEORGE, RB;ROTHWELL, NJ
本研究的目的是评估细菌感染是否刺激耗氧量和棕色脂肪组织（BAT）的活动。感染嗜肺军团菌的豚鼠在感染后第24天表现出明显的发热和静息耗氧量（VO2）显著增加（33%）。此时，摄食量和体重正常，从感染动物中提取的BAT的体外产热活性比对照豚鼠高64%。VO2和BAT活性下降到控制值48小时感染的动物变得奄奄一息，在此期间的食物摄入量显着减少。细菌感染通常与发热有关，发热是由产热增加和热损失减少引起的。对感染和损伤的高代谢反应可能涉及与非颤抖性产热相似的机制（1，2，3）。对实验室啮齿动物的研究倾向于集中使用细菌内毒素（如2），其不能模拟感染反应的所有方面，特别是因为它们的寿命短，耐受性快。我们在这里报告的研究结果使用肺炎感染与L。豚鼠体内的嗜肺菌该研究的目的是确定导致体重减轻的细菌感染是否与高代谢和BAT激活有关。
The objective of this study was to assess whether bacterial infection stimulates oxygen consumption and brown adipose tissue (BAT) activity. Guinea pigs infected with Legionella pneumophila showed marked fever and a significant (33%) increase in resting oxygen consumption (VO2), 24th after infection. At this time, food intake and body weight were normal and the in vitro thermogenic activity of BAT taken from infected animals was elevated by 64% above that of control guinea pigs. VO2 and BAT activity fell to control values by 48h as infected animals became moribund and over this period food intake was markedly reduced. Bacterial infection is frequently associated with fever, which is generated by both increased heat production and reduced heat loss. Hypermetabolic responses to infection and injury may involve similar mechanisms to non-shivering thermogenesis (1,2,3). Studies on laboratory rodents have tended to concentrate on the use of bacterial endotoxins (eg 2), which do not mimic all aspects of the responses to infection, particularly since they are short-lived and are rapidly tolerated. We report here the results of the study using a pneumonia infection with L. pneumophila in the guinea pig. The objective of the study was to determine whether bacterial infection which causes weight loss is associated with hypermetabolism and activation of BAT.