Helical Chiral 2,2′-Bipyridine N- Monoxides as Catalysts in the Enantioselective Propargylation of Aldehydes with Allenyltrichlorosilane
Helical Chiral 2,2′-Bipyridine N- Monoxides as Catalysts in the Enantioselective Propargylation of Aldehydes with Allenyltrichlorosilane
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DOI：
10.1021/ol200102c
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发表时间：
2011-04-01
期刊：
影响因子：
5.2
通讯作者：
Takenaka, Norito
中科院分区：
文献类型：
--
作者：
Chen, Jinshui;Captain, Burjor;Takenaka, Norito
采用新型螺旋手性2，2 ′-联吡啶N-一氧化物催化剂和丙二烯基三氯硅烷实现了高对映选择性合成高炔丙醇。该方法可进一步推广到N-酰腙的对映体和区域选择性炔丙基化反应。
A highly enantioselective synthesis of homopropargylic alcohols is achieved by using the new helical chiral 2,2'-bipyridine N-monoxide catalyst and allenyltrichlorosilane. This method can be further extended to the enantio- and regioselective propargylation of N-acylhydrazones.