DETECTION OF CLOSTRIDIUM-PERFRINGENS AND ITS ENTEROTOXIN IN CASES OF SPORADIC DIARRHEA
DETECTION OF CLOSTRIDIUM-PERFRINGENS AND ITS ENTEROTOXIN IN CASES OF SPORADIC DIARRHEA
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DOI：
10.1136/jcp.45.7.609
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发表时间：
1992-07-01
影响因子：
3.4
通讯作者：
HUTCHINSON, DN
中科院分区：
文献类型：
--
作者：
BRETT, MM;RODHOUSE, JC;HUTCHINSON, DN
目的：方法采用酶联免疫吸附试验（ELISA）和反相乳胶凝集试验（RPLA）对818例散发性腹泻患者粪便标本进行产气荚膜梭菌肠毒素检测。在818例病例中，有56例（6.8%）确定产气荚膜梭菌肠毒素是散发性腹泻的原因。在大多数情况下，腹泻时间延长（3天或更长）。年龄从3个月到89岁不等，但大多数患者年龄超过60岁。结论：这些结果表明，当不存在食物消耗或交叉感染等原因时，产气荚膜梭菌可能是散发腹泻病例的原因，尤其是在老年人中。
Aims: To determine the incidence of sporadic and apparently non-food related diarrhoea associated with Clostridium perfringens enterotoxin.Methods- Enzyme linked immunosorbent assay (ELISA) and reversed phase latex agglutination (RPLA) were used to detect C perfringens enterotoxin in faecal specimens from 818 sporadic cases of diarrhoea.Results: C perfringens enterotoxin was identified as a cause of sporadic diarrhoea in 56 of 818 (6.8%) cases. Diarrhoea was prolonged (three days or more) in most cases. Ages ranged from 3 months to 89 years, although most patients were over 60 years of age.Conclusions: These results suggest that C perfringens may be a cause of sporadic cases of diarrhoea when causes such as food consumption or cross-infection are absent, particularly in the elderly.