Psychometric, polysomnographic, and neuroendocrine measures in subjects at high risk for psychiatric disorders: preliminary results.
Psychometric, polysomnographic, and neuroendocrine measures in subjects at high risk for psychiatric disorders: preliminary results.
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精神疾病高危受试者的心理测量、多导睡眠图和神经内分泌测量：初步结果。
DOI：
10.1159/000119428
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发表时间：
1990
影响因子：
3.2
通讯作者：
F. Holsboer
中科院分区：
文献类型：
--
作者：
J. Krieg;C. Lauer;L. Hermle;U. von Bardeleben;T. Pollmächer;F. Holsboer
我们报告了 12 名精神疾病高家族风险受试者和 10 名非高风险健康受试者的心理测量、多导睡眠图和神经内分泌状态。高风险先证者的心理测量结果显示，“压力人格”模式加重，神经质得分增加。他们的整夜脑电图睡眠往往比对照组浅（即睡眠效率降低、觉醒更频繁、慢波睡眠更少），而他们的快速眼动睡眠参数没有差异。在用地塞米松预处理后，用促肾上腺皮质激素释放激素挑战边缘-下丘脑-垂体-肾上腺皮质系统，各组之间的皮质醇分泌没有差异。然而，在个体层面上，除一名受试者外，所有高风险受试者均被发现在所检查的三个州中的至少一个州中表现突出。
We report on the psychometric, polysomnographic, and neuroendocrine status of 12 subjects at high familial risk for psychiatric disorders and of 10 healthy subjects not at high risk. The psychometric measurements in the high-risk probands revealed an accentuated 'stress personality' pattern and an increased neuroticism score. Their all-night EEG sleep tended to be shallower than that of the control subjects (i.e., decreased sleep efficiency, more frequent awakenings, less slow-wave sleep), whereas they did not differ on REM sleep parameters. The challenge of the limbic-hypothalamic-pituitary-adrenocortical system with corticotropin-releasing hormone after pretreatment with dexamethasone yielded no differences in cortisol secretion between the groups. On an intraindividual level, however, all subjects at high risk except one were found to be conspicuous in at least one of the three states examined.