Statistical shape analysis of neuroanatomical structures based on medial models
Statistical shape analysis of neuroanatomical structures based on medial models
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DOI：
10.1016/s1361-8415(02)00110-x
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发表时间：
2003-09-01
影响因子：
10.9
通讯作者：
Weinberger, D
中科院分区：
文献类型：
--
作者：
Styner, M;Gerig, G;Weinberger, D
了解解剖对象的生物变异性对于统计形状分析和区分健康和病理结构是必不可少的。本文描述了一种新的方法，该方法将对象群体的可变性融入到特征3D形状模型的生成中。所提出的形状表示是从细尺度球谐(SPHARM)边界描述派生出来的粗采样中值描述。该中间描述由具有固定图属性的中间样本(m-rep)的网络组成。使用修剪的3D Voronoi骨架从预定义的形状空间自动计算中间模型。提出了一种由形状空间确定稳定的中间分支拓扑的新方法。在中间流形上定义了内部坐标系和形状之间的隐式对应。几项对生物结构的研究清楚地表明，这种新颖的表示法有望以自然和直观的方式描述形状变化。一项新的关于同卵和异卵双胞胎在侧脑室形状上的群体差异的内侧形状相似性研究表明，局部和全局形状的有意义和强大的代表性。(C)2003爱思唯尔B.V.保留所有权利。
Knowledge about the biological variability of anatomical objects is essential for statistical shape analysis and discrimination between healthy and pathological structures. This paper describes a novel approach that incorporates the variability of an object population into the generation of a characteristic 3D shape model. The proposed shape representation is a coarse-scale sampled medial description derived from a fine-scale spherical harmonics (SPHARM) boundary description. This medial description is composed of a net of medial samples (m-rep) with fixed graph properties. The medial model is computed automatically from a predefined shape space using pruned 3D Voronoi skeletons. A new method determines the stable medial branching topology from the shape space. An intrinsic coordinate system and an implicit correspondence between shapes is defined on the medial manifold. Several studies of biological structures clearly demonstrate that the novel representation has the promise to describe shape changes in a natural and intuitive way. A new medial shape similarity study of group differences between monozygotic and dizygotic twins in lateral ventricle shape demonstrates the meaningful and powerful representation of local and global form. (C) 2003 Elsevier B.V. All rights reserved.