Cecropin Suppresses Human Hepatocellular Carcinoma BEL-7402 Cell Growth and Survival in vivo without Side-Toxicity
Cecropin Suppresses Human Hepatocellular Carcinoma BEL-7402 Cell Growth and Survival in vivo without Side-Toxicity
复制标题
天蚕素在体内抑制人肝细胞癌 BEL-7402 细胞生长和存活，且无副作用
DOI：
10.7314/apjcp.2014.15.13.5433
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发表时间：
2014-01-01
影响因子：
--
通讯作者：
Zhu, Jia-Yong
中科院分区：
文献类型：
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作者：
Jin, Xiao-Bao;Wang, Ying-Jiao;Zhu, Jia-Yong
针对肝细胞癌的常规化疗通常会引起各种副作用。我们前期的研究表明家蝇抗菌肽在体外能诱导人肝癌BEL-7402细胞凋亡。但是，天蚕素在体内是否对BEL-7402细胞有抑制作用以及可能的副作用仍不清楚。本研究证实了天蚕素在体内的抑瘤作用，并进一步有力地表明，天蚕素在体内对BEL-7402细胞的细胞毒性可能主要来自其促凋亡作用。具体而言，我们发现天蚕素在荷瘤小鼠中没有明显的副作用，因为它没有明显的血液毒性以及内脏毒性。因此，天蚕素可能是一个潜在的候选人，为进一步研究作为一种抗肝癌的药物。
Conventional chemotherapy against hepatocellular carcinoma typically causes various side effects. Our previous study showed that cecropin of Musca domestica can induce apoptosis in human hepatocellular carcinoma BEL-7402 cells in vitro. However, whether cecropin inhibits BEL-7402 cell in vivo and the question of possible side effects remained undentified. The present study confirmed tumor-inhibitory effects of cecropin in vivo, and furthermore strongly suggested that cecropin cytotoxicity in BEL-7402 cells in vivo may be mainly derived from its pro-apoptotic action. Specifically, we found that cecropin exerted no obvious side effects in tumor-bearing mice as it had no significant hematoxicity as well as visceral toxicity. Therefore, cecropin may be a potential candidate for further investigation as an antitumor agent against hepatocellular carcinoma.