The maize abnormal chromosome 10 meiotic drive haplotype: a review
The maize abnormal chromosome 10 meiotic drive haplotype: a review
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DOI：
10.1007/s10577-022-09693-6
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发表时间：
2022-06
影响因子：
2.6
通讯作者：
R. Dawe
中科院分区：
文献类型：
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作者：
R. Dawe
玉米异常10号染色体(AB10)单倍型编码一个减数分裂驱动系统，该系统将异染色结转化为着丝粒样体，并通过雌性减数分裂优先分离。AB10最早是在20世纪40年代被描述的，并得到了广泛的研究。在这里，我提供了一个全面的文献回顾，从发现旋钮和AB10开始，然后是经典文献，最后是分子结构和机制。AB10单倍型的定义特征是它的两个特殊的动蛋白，kinesin driver和tr-1 kinesin，它们激活了包含不同类别串联重复序列的节点处的新着丝粒。在大多数AB10单倍型中，两个Kinesin/Knob系统协同工作以促进最大减数分裂驱动。然而，最近的解释表明，每个Kinesin/Knob系统都可以作为一个独立的减数分裂驱动因素发挥作用，在某些情况下，它们相互竞争。AB10在整个基因组中以低频率存在，并通过促进整个基因组中结节的形成显著扩大了基因组的大小。
The maize abnormal chromosome 10 (Ab10) haplotype encodes a meiotic drive system that converts heterochromatic knobs into centromere-like bodies that are preferentially segregated through female meiosis. Ab10 was first described in the 1940s and has been intensively studied. Here I provide a comprehensive review of the literature, starting from the discovery of knobs and Ab10, preceding through the classic literature, and finishing with molecular structure and mechanisms. The defining features of the Ab10 haplotype are its two specialized kinesins,Kinesin driverandTR-1 kinesin, that activate neocentromeres at knobs containing different classes of the tandem repeat. In most Ab10 haplotypes, the two kinesin/knob systems cooperate to promote maximum meiotic drive. However, recent interpretations suggest that each kinesin/knob system can function as an independent meiotic driver and that in some cases they compete with each other. Ab10 is present at low frequencies throughout the genusZeaand has significantly expanded genome size by promoting the formation of knobs throughout the genome.